PA14 Gene Annotations
Genomic Sequencing of Pseudomonas aeruginosa strain PA14
In parallel with the Pseudomonas aeruginosa strain PA14 Non-Redundant Transposon Insertion Mutant Library, we are in the process of sequencing and annotating the PA14 genome.
Pseudomonas aeruginosa is an important soil bacterium, with a complex metabolism capable of degrading polycyclic aromatic hydrocarbons, and producing interesting, biologically active secondary metabolites including quinolones, rhamnolipids, lectins, hydrogen cyanide, and phenazines. Production of these products is likely controled by complex regulatory networks making Pseudomonas aeruginosa adaptable both to free-living and pathogenic lifestyles. The complexity of its metabolism is reflected in a relatively large genome size (about 6.5 Mb).
In addition to being able to colonize a wide variety of environments, Pesudomonas aeruginosa is also a pathogen with a wide host range. PA14, a clinical isolate from a human burn patient, has been demonstrated to cause pathogenesis in such diverse hosts as humans, mice, Caenorhabditis elegans, Drosophila melanogaster, and Arabidopsis thaliana. PA14 is also an excellent model for the study of pathogenesis and biofilm formation. The PA14 genome sequence will facilitate the characterization of the Pseudomonas aeruginosa strain PA14 Transposon Insertion Mutant Library.
This research has been funded, in part, by DOE-GTL, the Department of Energy Genomes To Life Program.
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