PA14 Gene Annotations

Genomic Sequencing of Pseudomonas aeruginosa strain PA14

In parallel with the Pseudomonas aeruginosa strain PA14 Non-Redundant Transposon Insertion Mutant Library, we are in the process of sequencing and annotating the PA14 genome.

Pseudomonas aeruginosa is an important soil bacterium, with a complex metabolism capable of degrading polycyclic aromatic hydrocarbons, and producing interesting, biologically active secondary metabolites including quinolones, rhamnolipids, lectins, hydrogen cyanide, and phenazines. Production of these products is likely controled by complex regulatory networks making Pseudomonas aeruginosa adaptable both to free-living and pathogenic lifestyles. The complexity of its metabolism is reflected in a relatively large genome size (about 6.5 Mb).

In addition to being able to colonize a wide variety of environments, Pesudomonas aeruginosa is also a pathogen with a wide host range. PA14, a clinical isolate from a human burn patient, has been demonstrated to cause pathogenesis in such diverse hosts as humans, mice, Caenorhabditis elegans, Drosophila melanogaster, and Arabidopsis thaliana. PA14 is also an excellent model for the study of pathogenesis and biofilm formation. The PA14 genome sequence will facilitate the characterization of the Pseudomonas aeruginosa strain PA14 Transposon Insertion Mutant Library.

This research has been funded, in part, by DOE-GTL, the Department of Energy Genomes To Life Program.

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To move around this site, the following navigation buttons will be visible at all times at the top of each page:

  • Start: returns you to this page
  • View Genes: view the annotation for one gene at a time, as well as a graphical representation of the surrounding genes. You can move to other genes by clicking on the graphical map, or by manually entering a new Locus Name, GeneID or Chromosomal Location and clicking the associated button.
  • Search Genes: find annotations of interest by searching individual data fields, combinations of fields, or all fields. Wildcard search terms are supported
  • Retrieve Sequence: retrieve PA14 sequence between any user-defined coordinates. To retrieve the entire sequence, go to the Downloads page.
  • Statistics: numbers of PA14 genes belonging to each of 28 functional categories and to each of 4 annotation confidence codes.
  • Downloads: download (a) the complete genome sequence, (b) a list of the predicted nucleotide sequences of all genes, (c) a list of the predicted amino acid sequences of all genes, or (d) complete gene annotation information in a tabular format.
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