ViewGene
Locus Name:
GeneID:
Location:

GeneID:3505
TrivialName: PA14_66330
AnnotatorUID:
Modification Date/Time:2006-04-06 13:01:23
LocusName:PA14_66330
PAO1 Ortholog Locus:PA5018
Sequence Length:648
Protein Length:215
Start: 5915201
Stop: 5915848
Strand: +
Type:
ChromosomeID:2
Status: ACTIVE
Frame Discrepancy: FALSE
Missense Discrepancy:FALSE
Comments:
Homology: gb|AAG08403.1|AE004914_4 (AE004914) peptide methionine sulfoxide reductase [Pseudomonas aeruginosa PAO1]
Identities = 214/215 (99%), Positives = 215/215 (100%)
Sequence:
ATGGTTCTGCGTTCTGAAATCCTCACCAAGAAAAGCGAGCTGCCCACGCCGGACCAGGCCCTGCCGGGTCGC
GAAAGCGCCATGCCGGTGCCCGAAGCGCACTTCGTCAACGGCCGCCCGCTGACCGCGCCGTTCCCCGCCGGC
CTGCAACAGGTGCTGTTCGGCATGGGCTGCTTCTGGGGCGCCGAGCGTCGCCTCTGGCAGCAACCGGGCGTC
TGGGTGACCGCGGTGGGTTATGCCGGCGGCTACACGCCGAACCCGACCTACGACGAAGTCTGCTCCGGCCTG
ACCGGCCACAGCGAGGTCGTGCTGGTGGTCTACAACCCGCAGGAGACCAGCTTCGAACAGCTGCTCAAGGTA
TTCTGGGAAGCCCACGACCCGACCCAGGGCATGCGCCAGGGCGGCGACATCGGCACCCAGTACCGCTCGGTG
ATCTACACCTTCGACGCGGCCCAGAAGGCCGCGGCCATGGCCAGCCGGGAGAACTTCCAGGCCGAACTGGCG
AAAGCCGGCTACGACCGCATCACCACCGAGATCGCCGACGTCCCGCCCTTCTACTACGCCGAGGCCTACCAC
CAGCAGTATCTGGCGAAGAACCCCAACGGCTACTGCGGCCTGGGCGGCACCGGGGTGTGCCTGCCGGCCTGA
Translation:
MVLRSEILTKKSELPTPDQALPGRESAMPVPEAHFVNGRPLTAPFPAGLQQVLFGMGCFWGAERRLWQQPGV
WVTAVGYAGGYTPNPTYDEVCSGLTGHSEVVLVVYNPQETSFEQLLKVFWEAHDPTQGMRQGGDIGTQYRSV
IYTFDAAQKAAAMASRENFQAELAKAGYDRITTEIADVPPFYYAEAYHQQYLAKNPNGYCGLGGTGVCLPA*
AnnotationID:3513GeneID:3505
AnnotatorUID: diggins
Modification Date/Time: 2005-04-26 10:10:17
Gene Name:msrA
Confidence Code:2
GeneProduct:peptide methionine sulfoxide reductase
Cell Localization:()
Synonyms:pms
Cell Localization Confidence Code:5
MolecularFunction:
Functional Category:(26) Translation, post-translational modification, degradation
Alternate Gene Product Name:
Functional Category Confidence Code:5
COGs:pfam01625
Secondary Functional Category(ies):
EC Number:1.8.4.6
Status:ACTIVE
Pathway:






 
Homology:
>gb|AAO53949.1| (AE016857) peptide methionine sulfoxide reductase [Pseudomonas
           syringae pv. tomato str. DC3000]
          Length = 215

 Score =  324 bits (831), Expect = 2e-88
 Identities = 152/215 (70%), Positives = 173/215 (80%)

>dbj|BAA16624.1| (D90899) peptide methionine sulfoxide reductase [Synechocystis sp.
           PCC 6803]
          Length = 222

 Score =  315 bits (808), Expect = 9e-86
 Identities = 139/209 (66%), Positives = 170/209 (81%)

>dbj|BAC08437.1| (AP005371) peptide methionine sulfoxide reductase
           [Thermosynechococcus elongatus BP-1]
          Length = 224

 Score =  306 bits (783), Expect = 7e-83
 Identities = 138/202 (68%), Positives = 162/202 (80%)








 
Structural Features:
pfam01625, PMSR, Peptide methionine sulfoxide reductase. 
This enzyme repairs damaged proteins. 
Methionine sulfoxide in proteins is reduced to methionine.
CD-Length = 158 residues, 100.0% aligned
Score =  227 bits (580), Expect = 7e-61
Identities = 84/160 (52%), Positives = 101/160 (63%), Gaps = 2/160 (1%)







   
Genomic Context:






   
Comment:


















    ReferenceID:7013




  
Author/Investigator(s):
        GenNotator





  
Title:
        




  
PubMed:
        


MedLine:
        




    
Source:






    
Reference Type:BLASTP 







    
Data:


    		




 
URL:

















    ReferenceID:24155




  
Author/Investigator(s):
        GenNotator





  
Title:
        CDD Search




  
PubMed:
        


MedLine:
        




    
Source:






    
Reference Type:RPSBLAST 







    
Data:


    		




 
URL:

















    ReferenceID:35043




  
Author/Investigator(s):
        





  
Title:
        CDD Search




  
PubMed:
        


MedLine:
        




    
Source:






    
Reference Type:Misc (text/plain)







    
Data:3505_cdd.html


    		




 
URL:

















    ReferenceID:35862




  
Author/Investigator(s):
        Milton ID, Hewitt CL, Harwood CR.





  
Title:
        Cloning and sequencing of a plasmid-mediated erythromycin resistance determinant from Staphylococcus xylosus.




  
PubMed:
        1426997


MedLine:
        




    
Source:
FEMS Microbiol Lett. 1992 Oct 1;76(1-2):141-7.






    
Reference Type:Journal 







    
Data:


    		




 
URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=1426997

















    ReferenceID:35863




  
Author/Investigator(s):
        Ross JI, Eady EA, Cove JH, Cunliffe WJ, Baumberg S, Wootton JC.





  
Title:
        Inducible erythromycin resistance in staphylococci is encoded by a member of the ATP-binding transport super-gene family.




  
PubMed:
        2233255


MedLine:
        




    
Source:
Mol Microbiol. 1990 Jul;4(7):1207-14.






    
Reference Type:Journal 







    
Data:


    		




 
URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2233255









           
Homologs By Global Alignment 

           

       



     
Gene ID:3505
           
Identity:

                               
                                   0%
                               
                                   10%
                               
                                   20%
                               
                                   30%
                               
                                   40%
                               
                                   50%
                               
                                   60%
                               
                                   70%
                               
                                   80%
                               
                                   90%
                               
                                   100%
                               
                             

                           

     
HomologID
                           Accession
                           Description
                           Length
                           PctIdentity
                           PctSimilarity
                           Gaps
                           Score
     

     
     
5590
                           PA5018_tr
                           translation of PA5018
                           215
                           99.53
                           99.99
                           0
                           1156.0
     

     
     
155930
                           gb|AAG08403.1|AE004914_4
                           (AE004914) peptide methionine sulfoxide reductase [Pseudomonas aeruginosa PAO1]
                           215
                           99.53
                           99.99
                           0
                           1156.0
     

     
     
155931
                           gb|AAO53949.1|
                           (AE016857) peptide methionine sulfoxide reductase [Pseudomonas syringae pv. tomato str. DC3000]
                           215
                           70.69
                           80.46
                           0
                           831.0
     

     
     
155933
                           dbj|BAB78041.1|
                           (AP003586) protein-methionine-S-oxide reductase [Nostoc sp. PCC 7120]
                           224
                           64.28
                           75.00
                           11
                           796.0
     

     
     
155935
                           emb|CAC39251.1|
                           (AJ312185) peptide methionine sulfoxide reductase [Ochrobactrum anthropi]
                           219
                           63.01
                           72.14
                           5
                           747.0
     

     






      

          
GC ORFID: 46507How Found: BLASTX

          
GC_TrimmedSeqID: 69Blast Result ID

          
Subject Sequence Name: t_PA5018Glimmer Score: 

          
Start: 5178884Stop: 5179531

          
Length: 648


          
Start Codon: ATGTruncated Start:

          
Stop Codon: TGATruncated Stop: 

          
Homolog: t_PA5018 translation of PA5018Homolog Bit Score 449.0

          
Other Homologs:  psyr_15may02_Scaffold6_revised_gene6834 (ORF: BLASTX 321.0), t_PA5018 (ORF: GLIMMER)

          
GC ORF Sequence

           
ATGGTTCTGCGTTCTGAAATCCTCACCAAGAAAAGCGAGCTGCCCACGCCGGACCAGGCCCTGCCGGGTCGC 
GAAAGCGCCATGCCGGTGCCCGAAGCGCACTTCGTCAACGGCCGCCCGCTGACCGCGCCGTTCCCCGCCGGC 
CTGCAACAGGTGCTGTTCGGCATGGGCTGCTTCTGGGGCGCCGAGCGTCGCCTCTGGCAGCAACCGGGCGTC 
TGGGTGACCGCGGTGGGTTATGCCGGCGGCTACACGCCGAACCCGACCTACGACGAAGTCTGCTCCGGCCTG 
ACCGGCCACAGCGAGGTCGTGCTGGTGGTCTACAACCCGCAGGAGACCAGCTTCGAACAGCTGCTCAAGGTA 
TTCTGGGAAGCCCACGACCCGACCCAGGGCATGCGCCAGGGCGGCGACATCGGCACCCAGTACCGCTCGGTG 
ATCTACACCTTCGACGCGGCCCAGAAGGCCGCGGCCATGGCCAGCCGGGAGAACTTCCAGGCCGAACTGGCG 
AAAGCCGGCTACGACCGCATCACCACCGAGATCGCCGACGTCCCGCCCTTCTACTACGCCGAGGCCTACCAC 
CAGCAGTATCTGGCGAAGAACCCCAACGGCTACTGCGGCCTGGGCGGCACCGGGGTGTGCCTGCCGGCCTGA