ViewGene
Locus Name:
GeneID:
Location:

GeneID:8
TrivialName: PA14_09280
AnnotatorUID:
Modification Date/Time:2006-04-06 13:01:23
LocusName:PA14_09280
PAO1 Ortholog Locus:PA4225
Sequence Length:5430
Protein Length:1809
Start: 790021
Stop: 795450
Strand: +
Type:
ChromosomeID:2
Status: ACTIVE
Frame Discrepancy: FALSE
Missense Discrepancy:FALSE
Comments:
Homology: gb|AAD55801.1|AF184622_1 (AF184622) pyochelin synthetase PchF [Pseudomonas aeruginosa]
Identities = 1805/1809 (99%), Positives = 1807/1809 (99%)
Sequence:
ATGAGCCTCGGCGAACTGCTGGAAACCTGCCGCAGCCGGCGCATCGAACTCTGGAGCGAGGCGGGCCGCCTG
CGCTATCGCGCCCCCCAGGGCGCCCTCGACGCCGGCCTCGCCGAGCGCCTGCGGGCCGAGCGCGAGGCCCTG
CTGGAACACCTGGAAGGCGGCCCTGGCTGGCGCGCCGAACCCGACCTGGCCCACCAGCGCTTCCCGCTGACC
CCGGTGCAGGCCGCCTACGTGCTGGGCCGCCAGGCGGCCTTCGACTACGGCGGTAACGCCTGCCAGCTGTAC
GCCGAGTACGACTGGCCGGCCGACACCGACCCGGCGCGCCTGGAGGCGGCCTGGAACGCCATGGTCGAGCGC
CACCCGATGCTGCGCGCGGTGATCGAGGACAACGCCTGGCAGCGCGTCCTGCCCGAGGTGCCCTGGCAGCGG
CTGACCGTGCATGCCTGCGCGGGGCTCGACGAGGCCGCTTTCCAGGCGCACCTGGAGCGGGTCCGCGAACGC
CTCGACCACGCCTGCGCGGCGCTCGACCAGTGGCCGGTCCTGCGCCCCGAGCTGAGTATCGGCCGGGATGAC
TGCGTACTGCACTGCTCGGTGGATTTCACCCTGGTCGACTACGCCAGCCTGCAATTGCTGCTTGGCGAATGG
CGCCGCCGCTATCTCGATCCGCAATGGACGGCGGAACCGCTGGAGGCGACCTTCCGCGACTATGTCGGCGTC
GAGCAGCGCCGACGCCAGTCGCCAGCCTGGCAGCGCGACCGCGACTGGTGGCTGGCGCGCCTCGACGCGCTG
CCGGGGCGTCCCGACCTGCCGCTGCGGGCGCAGCCGGACACCCGGTCCACGCGCTTCCGGCACTTCCACGCG
CGCCTCGACGAGGCCGCCTGGCAGGCGCTCGGCGCGCGCGCCGGCGAACACGGCCTGAGCGCTGCCGGCGTG
GCCCTGGCGGCCTTCGCCGAGACCATCGGTCGCTGGAGCCAGGCACCGGCGTTCTGTCTCAACCTGACGGTA
CTCAACCGGCCGCCGCTGCATCCGCAGCTGGCGCAGGTGCTCGGTGACTTCACCGCTCTAAGCCTGCTGGCG
GTGGACAGCCGCCACGGCGACAGTTTCGTCGAGCGCGCCCGCCGCATCGGCGAGCAGATGTTCGACGACCTC
GACCATCCGACCTTCAGCGGCGTCGACCTGCTGCGCGAACTGGCGCGCCGGCGCGGTCGCGGCGCCGACCTG
ATGCCGGTGGTGTTCACCAGTGGCATCGGCAGCGTGCAGCGCCTGCTCGGCGATGGCGAGGCGCCGCGCGCG
CCACGCTACATGATCAGCCAGACCCCGCAGGTCTGGCTGGACTGCCAGGTCACCGACCAGTTCGGCGGCCTG
GAGATCGGCTGGGACGTACGCCTCGGGTTGTTCCCCGAGGGGCAGGCGGAAGCCATGTTCGACGACTTCGTC
GGGCTGCTCCGGCGCCTGGCGCAGAGCCCGCGCGCCTGGACCGACGGCGATGCCACGGAACCCGTCGAGGCG
CCGCCGCAGGCGTTGCCCGGTAGTGCCCGGAGCATCGCCGCCGGTTTCGCCGAGCGTGCCCTGCTGACCCCC
GACGCCACGGTGATCCACGATGCCGCCGGCAGCTACAGCTACCGCCAGGTCGCCCAGCACGCCAGCGCCCTG
CGCCGCGTCCTGGAAGCGCACGGCGCGGGCCGTGGCCGGCGGGTCGCGGTGATGCTGCCGAAAAGCGCCGCG
CAATTGGTCGCGGTGATCGGCAtcctCcAGGCCGGCGCAGCCTATGTGCCGGTGGACATCCGCCAGCCGCCG
CTGCGGCGCCAGGcgATCctcGCCAgccccgaAGTGgtcGcctgggtctGcctGGaAagcgATGTCCcgaac
gCcGgctgcgcctgcgtGGCCATCGACCGgctgGCCGccgaCAGCGCCtgGCCGCCACCGCCCGCGGCGGAG
GTGGCGGCGGACGACCTCGCCTACGTGATCTACACCTCCGGCTCCACCGGCACGCCCAAGGGCGTGATGCTC
AGCCATGCGGCGGTGAGCAACACGCTGCTCGACATCAACCAGCGCTACGGCGTCGACGCCAACGACCGCGTC
CTCGGCCTCGCCGAGCTGAGCTTCGACCTTTCGGTCTACGACTTCTTCGGCGCCACCGCGGCGGGGGCCCAG
GTGGTCCTCCCGGACCCGGCGCGCGGCAGCGATCCTTCGCATTGGGCGGAACTGCTGGAACGCCACGCCATC
ACCCTGTGGAACTCGGTGCCGGCCCAGGGCCAGATGCTCATCGATTACCTGGAGAGCGAGCCGCAACGCCAC
CTGCCGGGACCGCGCTGCGTGCTCTGGTCCGGCGACTGGATTCCAGTCAGCCTGCCGACCCGCTGGTGGCGG
CGCTGGCCGGACAGCGCGCTGTTCAGCCTGGGCGGCGCTACCGAGGCGGCGATCTGGTCGATCGAGCAGCCG
ATCCGTCCGCAGCACACCGAGCTGGCCAGCATCCCTTATGGCCGTGCCCTGCGCGGGCAGAGCGTGGAAGTC
CTGGATGCCCGCGGGCGGCGCTGCCCGCCGGGCGTGCGCGGCGAGATCCATATCGGCGGGGTGGGCCTGGCG
CTCGGCTACGCCGGCGATCCGCAGCGCACCGCCGAACGCTTCGTCCGTCACCCCGATGGCCGTCGCCTGTAT
CGCACCGGCGACCTCGGCCGCTACCTGGCCGACGGCAGCATCGAGTTCCTCGGCCGCGAGGACGACCAGGTG
AAGATTCGCGGCCACCGTATCGAACTGGCCGAGCTGGACGCCGCGCTGTGCGCCCATCCGCAGGTCAACCTG
GCGGCCACCGTGGTGCTCGGTGAGACCCACGAGCGCAGCCTGGCCAGCTTCGTCACCCTGCATGCGCCGGCG
GAGGCTGGCGAGGACCCGCGCACGGCGCTCGACACGGTGCGCCAGCGGGCGGCCCAGGCCTTGCGCCGCGAC
TGGGGCAGCGAGGAGGGCATCGCCGCGGCGGTGGCCGCACTCGACCGTGCCTGCCTCGCCTCGTTGGCCGCC
TGGCTGGCCGGCAGCGGTCTGTTCGCGAGTGCGACGCCGCTGGACTTCGCCACCCTGTGCCAGCGCCTGGGT
ATCGCCGAGGCGCGCCAGCGCCTGCTGCGCCACTGGTTGCGCCAGCTGGAGGAGGGCGGCTACCTGCGCGCC
GAGGGCGAGGGCTGGCTGGGCTGCGCCGAGCGTCCCGCGCAGAGTCCGGAGGACGCCTGGACGGCGTTCGCC
GGCTGCGCGCCGGCGGCGCTCTGGCCGGCCGAGCTGGTCGCCTACCTGCGTGACAGCGCGCAATCCCTCGGC
GAGCAACTGGCCGGGCGGATCAGCCCGGCGGCGCTGATGTTCCCGCAGGGCTCGGCGCGCATCGCCGAGGCC
ATGTACAGCCAGGGCCTGCATGCCCAGGCGCTGCACGAGGCCATGGCCGAGGCCATCGCCGCCATCGTCGAG
CGCCAGCCGCAACGGCGCTGGCGCCTGCTGGAGCTTGGCGCCGGCACCGCCGCCGCCAGCCGCGCGGTGATC
GCCCGGTTGGCGCCGCTGGTGCAGCGAGGGACGGAGGTGGACTACCTGTTCACCGACGTTTCCAGCTACTTC
CTCGCCGCCGCCCGCGAGCGCTTCGCCGACCAGCCGTGGGTACGCTTCGGCCGCTTCGACATGAACGGCGAT
CTTCTCGACCAGGGCGTGGCGCCGCACTCGGTGGATATCCTGCTCAGCTCCGGGGCCTTGAACAACGCGCTG
GACACCCCGGCGCTGCTGGCCGGCCTGCGCGAGCTGCTGAGCGCCGACGCCTGGCTGGTGATCCAGGAACTG
ACGCGCGAGCACAACGAGATCAGCGTCAGCCAGAGCCTGATGATGGAAAACCCGCGCGACCTCCGCGACGAG
CGCCGCCAACTGTTCGTCCACACCGGGCAATGGCTGGAGTGGCTGGCGGCACAGGGTGGCGACCTGGCTTGC
GGGGTGGTGCCGCCGGGCAGCGCTCTCGACCTGCTTGGCTACGATGTCCTGCTGGCTCGCTGCAAGACCGAC
CGCGCCCGCCTGGAGCCGGCCGAGCTGCTGGCCTTCGTCGAAGCGCGGGTGCCGCGCTACATGCTCCCGGCG
CAGTTGCGCGTGCTCGAACGCCTGCCGGTCACCGGCAACGGCAAGATCGACCGCAAGGCCCTGACCGGCTTT
GCCCGCCAGCCCCAGGCGGACCTTCGGCATGGCGTCGCGCAGGCACCGGCCGACGAGCTGGAGAGTGCGTTG
CTGGCACTCTGGCGAGAGGTGTTGGACAACCCGTCGCTGGGCGTCGAGCAAGACTTCTTCGGGGCTGGCGGC
GACTCGCTGTTGATCGCTCAGTTGATCGCCCGTTTGCGCGAACGCCTGGAAAGCGCCCGCCGGCATCCGTTC
GATCGCCTGCTGCGCTGGGCGCTCAGCCAGCCGACGCCGCGCGGCCTGGCCGAACGCTTGCGCAGCGCGCCG
GAAGAGGGTCGTGGGCCGGCCCTGGCCGCGGCGCGCGGCGTCGCCCCGGCGCAGACTGGCATGTCGCGCGCA
CCGCTCGCCGAGGGCGCGGTGGCGCTCGACCCGCTGGTGCGCCTGGTGCCCGGCGAGGGCGTGCCGCGGGTG
CTGGTCCACGAAGGCCTCGGCACGCTGCTGCCGTACCGCCCGCTGCTTCGCGCCCTGGGTGAGGGGCGGCCG
TTGCTGGGGCTGGCCGTGCATGACAGCGACGCCTACCTGGCGATCCCCGCCGAGTATCTCAACGCCTGTCTC
GGCCGCCGCTACGCCGAGGCGCTCCATGGCGCCGGGCTGCGTGAGGTCGACCTGCTCGGCTACTGCTCCGGC
GGGCTGGTCGCCCTGGAGACCGCCAAGTCTCTGCTCCAGCGCGGGGTGCGCGTGCGCCAGCTGGATATCGTC
TCCAGCTACCGGATTCCCTACCGGGTGGACGACGAGCGCTTGCTGTTGTTCAGCTTCGCCGCGACCCTCGGA
CTGGATACCGCGGCGCTCGGCTTCCCCGCGCCGGAACGTCTCGGCCAGGCGGTGCAGGCGGCGCTCGCGCAG
ACACCGGAGCGCCTGGGCGCCGAGGCGCTGGCGGGGCTACCGGGCCTGGCCGATCTCGTCGCCCTGCGCGGC
CGCGTGCTACAGGCGGCCAGCGGTAGTGCCGACGCCGCCAGCGTCGAACGCGACACCCTCTACCGGCTGTTC
TGTCACTCGGTGCGTGCCAGCCAGGCCGAGGCGCTGGAGCCCTACGTCGGCGCGCTGCGGCTGTTCGTGCCG
GACGCCGGCAACCCATTGGTGCCGCGCTACGCCGAGGCCCTGGAGACCCAATGGCGGGCCGCCGCGCTCGGC
GCGTGCGGCATCCACGAGGTGCCCGGCGGGCACTTCGACTGCCTGGGCGAAGCCCTGGCGCAATCCCTGTCG
AAACCCATGCCAGAGGAGGCGAGCCAATGA
Translation:
MSLGELLETCRSRRIELWSEAGRLRYRAPQGALDAGLAERLRAEREALLEHLEGGPGWRAEPDLAHQRFPLT
PVQAAYVLGRQAAFDYGGNACQLYAEYDWPADTDPARLEAAWNAMVERHPMLRAVIEDNAWQRVLPEVPWQR
LTVHACAGLDEAAFQAHLERVRERLDHACAALDQWPVLRPELSIGRDDCVLHCSVDFTLVDYASLQLLLGEW
RRRYLDPQWTAEPLEATFRDYVGVEQRRRQSPAWQRDRDWWLARLDALPGRPDLPLRAQPDTRSTRFRHFHA
RLDEAAWQALGARAGEHGLSAAGVALAAFAETIGRWSQAPAFCLNLTVLNRPPLHPQLAQVLGDFTALSLLA
VDSRHGDSFVERARRIGEQMFDDLDHPTFSGVDLLRELARRRGRGADLMPVVFTSGIGSVQRLLGDGEAPRA
PRYMISQTPQVWLDCQVTDQFGGLEIGWDVRLGLFPEGQAEAMFDDFVGLLRRLAQSPRAWTDGDATEPVEA
PPQALPGSARSIAAGFAERALLTPDATVIHDAAGSYSYRQVAQHASALRRVLEAHGAGRGRRVAVMLPKSAA
QLVAVIGILQAGAAYVPVDIRQPPLRRQAILASPEVVAWVCLESDVPNAGCACVAIDRLAADSAWPPPPAAE
VAADDLAYVIYTSGSTGTPKGVMLSHAAVSNTLLDINQRYGVDANDRVLGLAELSFDLSVYDFFGATAAGAQ
VVLPDPARGSDPSHWAELLERHAITLWNSVPAQGQMLIDYLESEPQRHLPGPRCVLWSGDWIPVSLPTRWWR
RWPDSALFSLGGATEAAIWSIEQPIRPQHTELASIPYGRALRGQSVEVLDARGRRCPPGVRGEIHIGGVGLA
LGYAGDPQRTAERFVRHPDGRRLYRTGDLGRYLADGSIEFLGREDDQVKIRGHRIELAELDAALCAHPQVNL
AATVVLGETHERSLASFVTLHAPAEAGEDPRTALDTVRQRAAQALRRDWGSEEGIAAAVAALDRACLASLAA
WLAGSGLFASATPLDFATLCQRLGIAEARQRLLRHWLRQLEEGGYLRAEGEGWLGCAERPAQSPEDAWTAFA
GCAPAALWPAELVAYLRDSAQSLGEQLAGRISPAALMFPQGSARIAEAMYSQGLHAQALHEAMAEAIAAIVE
RQPQRRWRLLELGAGTAAASRAVIARLAPLVQRGTEVDYLFTDVSSYFLAAARERFADQPWVRFGRFDMNGD
LLDQGVAPHSVDILLSSGALNNALDTPALLAGLRELLSADAWLVIQELTREHNEISVSQSLMMENPRDLRDE
RRQLFVHTGQWLEWLAAQGGDLACGVVPPGSALDLLGYDVLLARCKTDRARLEPAELLAFVEARVPRYMLPA
QLRVLERLPVTGNGKIDRKALTGFARQPQADLRHGVAQAPADELESALLALWREVLDNPSLGVEQDFFGAGG
DSLLIAQLIARLRERLESARRHPFDRLLRWALSQPTPRGLAERLRSAPEEGRGPALAAARGVAPAQTGMSRA
PLAEGAVALDPLVRLVPGEGVPRVLVHEGLGTLLPYRPLLRALGEGRPLLGLAVHDSDAYLAIPAEYLNACL
GRRYAEALHGAGLREVDLLGYCSGGLVALETAKSLLQRGVRVRQLDIVSSYRIPYRVDDERLLLFSFAATLG
LDTAALGFPAPERLGQAVQAALAQTPERLGAEALAGLPGLADLVALRGRVLQAASGSADAASVERDTLYRLF
CHSVRASQAEALEPYVGALRLFVPDAGNPLVPRYAEALETQWRAAALGACGIHEVPGGHFDCLGEALAQSLS
KPMPEEASQ*
AnnotationID:18GeneID:8
AnnotatorUID: diggins
Modification Date/Time: 2005-01-06 06:06:03
Gene Name:pchF
Confidence Code:1
GeneProduct:pyochelin synthetase PchF
Cell Localization:()
Synonyms:
Cell Localization Confidence Code:5
MolecularFunction:
Functional Category:(27) Transport of small molecules
Alternate Gene Product Name:
Functional Category Confidence Code:5
COGs:COG1020,pfam00501
Secondary Functional Category(ies):secondary metabolites, biosynthesis, transport, and catabolism
EC Number:
Status:ACTIVE
Pathway:






 
Homology:
>emb|CAC17500.1| (AL939132) putative non-ribosomal peptide synthase [Streptomyces
            coelicolor A3(2)]
          Length = 1842

 Score = 1102 bits (2849), Expect = 0.0
 Identities = 734/1882 (39%), Positives = 972/1882 (51%), Gaps = 125/1882 (6%)

>gb|AAG02364.1|AF210249_23 (AF210249) peptide synthetase NRPS2-1 [Streptomyces verticillus]
          Length = 2626

 Score =  636 bits (1641), Expect = 0.0
 Identities = 389/926 (42%), Positives = 507/926 (54%), Gaps = 28/926 (3%)








 
Structural Features:
COG1020, EntF, Non-ribosomal peptide synthetase modules and related proteins 
[Secondary metabolites biosynthesis, transport, and catabolism]

pfam00501, AMP-binding, AMP-binding enzyme.








   
Genomic Context:






   
Comment:


















    ReferenceID:19




  
Author/Investigator(s):
        GenNotator





  
Title:
        




  
PubMed:
        


MedLine:
        




    
Source:






    
Reference Type:BLASTP 







    
Data:


    		




 
URL:

















    ReferenceID:17161




  
Author/Investigator(s):
        GenNotator





  
Title:
        CDD Search




  
PubMed:
        


MedLine:
        




    
Source:






    
Reference Type:RPSBLAST 







    
Data:


    		




 
URL:

















    ReferenceID:36925




  
Author/Investigator(s):
        





  
Title:
        CDD Search




  
PubMed:
        


MedLine:
        




    
Source:






    
Reference Type:Misc (text/plain)







    
Data:8_cdd.html


    		




 
URL:

















    ReferenceID:37013




  
Author/Investigator(s):
        Reimmann C, Serino L, Beyeler M, Haas D.





  
Title:
        Dihydroaeruginoic acid synthetase and pyochelin synthetase, products of the pchEF genes, are induced by extracellular pyochelin in Pseudomonas aeruginosa.




  
PubMed:
        9846750


MedLine:
        




    
Source:
Microbiology. 1998 Nov;144 ( Pt 11):3135-48.






    
Reference Type:Journal 







    
Data:


    		




 
URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=99061207&dopt=Abstract









           
Homologs By Global Alignment 

           

       



     
Gene ID:8
           
Identity:

                               
                                   0%
                               
                                   10%
                               
                                   20%
                               
                                   30%
                               
                                   40%
                               
                                   50%
                               
                                   60%
                               
                                   70%
                               
                                   80%
                               
                                   90%
                               
                                   100%
                               
                             

                           

     
HomologID
                           Accession
                           Description
                           Length
                           PctIdentity
                           PctSimilarity
                           Gaps
                           Score
     

     
     
8405
                           gb|AAD55801.1|AF184622_1
                           (AF184622) pyochelin synthetase PchF [Pseudomonas aeruginosa]
                           1809
                           99.77
                           99.88
                           0
                           9345.0
     

     
     
19
                           PA4225_tr
                           translation of PA4225
                           1809
                           98.72
                           99.06
                           0
                           9249.0
     

     
     
8406
                           gb|AAG07613.1|AE004839_6
                           (AE004839) pyochelin synthetase [Pseudomonas aeruginosa PAO1]
                           1809
                           98.72
                           99.06
                           0
                           9249.0
     

     
     
8407
                           gb|AAC83657.1|
                           (AF074705) pyochelin synthetase [Pseudomonas aeruginosa]
                           1809
                           98.39
                           98.72
                           0
                           9213.0
     

     
     
8408
                           emb|CAD89774.1|
                           (AJ557546) MelC protein [Melittangium lichenicola]
                           1923
                           25.79
                           34.73
                           714
                           1756.0
     

     






      

          
GC ORFID: 43010How Found: BLASTX

          
GC_TrimmedSeqID: 69Blast Result ID

          
Subject Sequence Name: t_PA4225Glimmer Score: 

          
Start: 4163916Stop: 4158487

          
Length: 5430


          
Start Codon: ATGTruncated Start:

          
Stop Codon: TGATruncated Stop: 

          
Homolog: t_PA4225 translation of PA4225Homolog Bit Score 3567.0

          
Other Homologs:  t_PA4225 (ORF: GLIMMER)

          
GC ORF Sequence

           
ATGAGCCTCGGCGAACTGCTGGAAACCTGCCGCAGCCGGCGCATCGAACTCTGGAGCGAGGCGGGCCGCCTG 
CGCTATCGCGCCCCCCAGGGCGCCCTCGACGCCGGCCTCGCCGAGCGCCTGCGGGCCGAGCGCGAGGCCCTG 
CTGGAACACCTGGAAGGCGGCCCTGGCTGGCGCGCCGAACCCGACCTGGCCCACCAGCGCTTCCCGCTGACC 
CCGGTGCAGGCCGCCTACGTGCTGGGCCGCCAGGCGGCCTTCGACTACGGCGGTAACGCCTGCCAGCTGTAC 
GCCGAGTACGACTGGCCGGCCGACACCGACCCGGCGCGCCTGGAGGCGGCCTGGAACGCCATGGTCGAGCGC 
CACCCGATGCTGCGCGCGGTGATCGAGGACAACGCCTGGCAGCGCGTCCTGCCCGAGGTGCCCTGGCAGCGG 
CTGACCGTGCATGCCTGCGCGGGGCTCGACGAGGCCGCTTTCCAGGCGCACCTGGAGCGGGTCCGCGAACGC 
CTCGACCACGCCTGCGCGGCGCTCGACCAGTGGCCGGTCCTGCGCCCCGAGCTGAGTATCGGCCGGGATGAC 
TGCGTACTGCACTGCTCGGTGGATTTCACCCTGGTCGACTACGCCAGCCTGCAATTGCTGCTTGGCGAATGG 
CGCCGCCGCTATCTCGATCCGCAATGGACGGCGGAACCGCTGGAGGCGACCTTCCGCGACTATGTCGGCGTC 
GAGCAGCGCCGACGCCAGTCGCCAGCCTGGCAGCGCGACCGCGACTGGTGGCTGGCGCGCCTCGACGCGCTG 
CCGGGGCGTCCCGACCTGCCGCTGCGGGCGCAGCCGGACACCCGGTCCACGCGCTTCCGGCACTTCCACGCG 
CGCCTCGACGAGGCCGCCTGGCAGGCGCTCGGCGCGCGCGCCGGCGAACACGGCCTGAGCGCTGCCGGCGTG 
GCCCTGGCGGCCTTCGCCGAGACCATCGGTCGCTGGAGCCAGGCACCGGCGTTCTGTCTCAACCTGACGGTA 
CTCAACCGGCCGCCGCTGCATCCGCAGCTGGCGCAGGTGCTCGGTGACTTCACCGCTCTAAGCCTGCTGGCG 
GTGGACAGCCGCCACGGCGACAGTTTCGTCGAGCGCGCCCGCCGCATCGGCGAGCAGATGTTCGACGACCTC 
GACCATCCGACCTTCAGCGGCGTCGACCTGCTGCGCGAACTGGCGCGCCGGCGCGGTCGCGGCGCCGACCTG 
ATGCCGGTGGTGTTCACCAGTGGCATCGGCAGCGTGCAGCGCCTGCTCGGCGATGGCGAGGCGCCGCGCGCG 
CCACGCTACATGATCAGCCAGACCCCGCAGGTCTGGCTGGACTGCCAGGTCACCGACCAGTTCGGCGGCCTG 
GAGATCGGCTGGGACGTACGCCTCGGGTTGTTCCCCGAGGGGCAGGCGGAAGCCATGTTCGACGACTTCGTC 
GGGCTGCTCCGGCGCCTGGCGCAGAGCCCGCGCGCCTGGACCGACGGCGATGCCACGGAACCCGTCGAGGCG 
CCGCCGCAGGCGTTGCCCGGTAGTGCCCGGAGCATCGCCGCCGGTTTCGCCGAGCGTGCCCTGCTGACCCCC 
GACGCCACGGTGATCCACGATGCCGCCGGCAGCTACAGCTACCGCCAGGTCGCCCAGCACGCCAGCGCCCTG 
CGCCGCGTCCTGGAAGCGCACGGCGCGGGCCGTGGCCGGCGGGTCGCGGTGATGCTGCCGAAAAGCGCCGCG 
CAATTGGTCGCGGTGATCGGCAtcctCcAGGCCGGCGCAGCCTATGTGCCGGTGGACATCCGCCAGCCGCCG 
CTGCGGCGCCAGGcgATCctcGCCAgccccgaAGTGgtcGcctgggtctGcctGGaAagcgATGTCCcgaac 
gCcGgctgcgcctgcgtGGCCATCGACCGgctgGCCGccgaCAGCGCCtgGCCGCCACCGCCCGCGGCGGAG 
GTGGCGGCGGACGACCTCGCCTACGTGATCTACACCTCCGGCTCCACCGGCACGCCCAAGGGCGTGATGCTC 
AGCCATGCGGCGGTGAGCAACACGCTGCTCGACATCAACCAGCGCTACGGCGTCGACGCCAACGACCGCGTC 
CTCGGCCTCGCCGAGCTGAGCTTCGACCTTTCGGTCTACGACTTCTTCGGCGCCACCGCGGCGGGGGCCCAG 
GTGGTCCTCCCGGACCCGGCGCGCGGCAGCGATCCTTCGCATTGGGCGGAACTGCTGGAACGCCACGCCATC 
ACCCTGTGGAACTCGGTGCCGGCCCAGGGCCAGATGCTCATCGATTACCTGGAGAGCGAGCCGCAACGCCAC 
CTGCCGGGACCGCGCTGCGTGCTCTGGTCCGGCGACTGGATTCCAGTCAGCCTGCCGACCCGCTGGTGGCGG 
CGCTGGCCGGACAGCGCGCTGTTCAGCCTGGGCGGCGCTACCGAGGCGGCGATCTGGTCGATCGAGCAGCCG 
ATCCGTCCGCAGCACACCGAGCTGGCCAGCATCCCTTATGGCCGTGCCCTGCGCGGGCAGAGCGTGGAAGTC 
CTGGATGCCCGCGGGCGGCGCTGCCCGCCGGGCGTGCGCGGCGAGATCCATATCGGCGGGGTGGGCCTGGCG 
CTCGGCTACGCCGGCGATCCGCAGCGCACCGCCGAACGCTTCGTCCGTCACCCCGATGGCCGTCGCCTGTAT 
CGCACCGGCGACCTCGGCCGCTACCTGGCCGACGGCAGCATCGAGTTCCTCGGCCGCGAGGACGACCAGGTG 
AAGATTCGCGGCCACCGTATCGAACTGGCCGAGCTGGACGCCGCGCTGTGCGCCCATCCGCAGGTCAACCTG 
GCGGCCACCGTGGTGCTCGGTGAGACCCACGAGCGCAGCCTGGCCAGCTTCGTCACCCTGCATGCGCCGGCG 
GAGGCTGGCGAGGACCCGCGCACGGCGCTCGACACGGTGCGCCAGCGGGCGGCCCAGGCCTTGCGCCGCGAC 
TGGGGCAGCGAGGAGGGCATCGCCGCGGCGGTGGCCGCACTCGACCGTGCCTGCCTCGCCTCGTTGGCCGCC 
TGGCTGGCCGGCAGCGGTCTGTTCGCGAGTGCGACGCCGCTGGACTTCGCCACCCTGTGCCAGCGCCTGGGT 
ATCGCCGAGGCGCGCCAGCGCCTGCTGCGCCACTGGTTGCGCCAGCTGGAGGAGGGCGGCTACCTGCGCGCC 
GAGGGCGAGGGCTGGCTGGGCTGCGCCGAGCGTCCCGCGCAGAGTCCGGAGGACGCCTGGACGGCGTTCGCC 
GGCTGCGCGCCGGCGGCGCTCTGGCCGGCCGAGCTGGTCGCCTACCTGCGTGACAGCGCGCAATCCCTCGGC 
GAGCAACTGGCCGGGCGGATCAGCCCGGCGGCGCTGATGTTCCCGCAGGGCTCGGCGCGCATCGCCGAGGCC 
ATGTACAGCCAGGGCCTGCATGCCCAGGCGCTGCACGAGGCCATGGCCGAGGCCATCGCCGCCATCGTCGAG 
CGCCAGCCGCAACGGCGCTGGCGCCTGCTGGAGCTTGGCGCCGGCACCGCCGCCGCCAGCCGCGCGGTGATC 
GCCCGGTTGGCGCCGCTGGTGCAGCGAGGGACGGAGGTGGACTACCTGTTCACCGACGTTTCCAGCTACTTC 
CTCGCCGCCGCCCGCGAGCGCTTCGCCGACCAGCCGTGGGTACGCTTCGGCCGCTTCGACATGAACGGCGAT 
CTTCTCGACCAGGGCGTGGCGCCGCACTCGGTGGATATCCTGCTCAGCTCCGGGGCCTTGAACAACGCGCTG 
GACACCCCGGCGCTGCTGGCCGGCCTGCGCGAGCTGCTGAGCGCCGACGCCTGGCTGGTGATCCAGGAACTG 
ACGCGCGAGCACAACGAGATCAGCGTCAGCCAGAGCCTGATGATGGAAAACCCGCGCGACCTCCGCGACGAG 
CGCCGCCAACTGTTCGTCCACACCGGGCAATGGCTGGAGTGGCTGGCGGCACAGGGTGGCGACCTGGCTTGC 
GGGGTGGTGCCGCCGGGCAGCGCTCTCGACCTGCTTGGCTACGATGTCCTGCTGGCTCGCTGCAAGACCGAC 
CGCGCCCGCCTGGAGCCGGCCGAGCTGCTGGCCTTCGTCGAAGCGCGGGTGCCGCGCTACATGCTCCCGGCG 
CAGTTGCGCGTGCTCGAACGCCTGCCGGTCACCGGCAACGGCAAGATCGACCGCAAGGCCCTGACCGGCTTT 
GCCCGCCAGCCCCAGGCGGACCTTCGGCATGGCGTCGCGCAGGCACCGGCCGACGAGCTGGAGAGTGCGTTG 
CTGGCACTCTGGCGAGAGGTGTTGGACAACCCGTCGCTGGGCGTCGAGCAAGACTTCTTCGGGGCTGGCGGC 
GACTCGCTGTTGATCGCTCAGTTGATCGCCCGTTTGCGCGAACGCCTGGAAAGCGCCCGCCGGCATCCGTTC 
GATCGCCTGCTGCGCTGGGCGCTCAGCCAGCCGACGCCGCGCGGCCTGGCCGAACGCTTGCGCAGCGCGCCG 
GAAGAGGGTCGTGGGCCGGCCCTGGCCGCGGCGCGCGGCGTCGCCCCGGCGCAGACTGGCATGTCGCGCGCA 
CCGCTCGCCGAGGGCGCGGTGGCGCTCGACCCGCTGGTGCGCCTGGTGCCCGGCGAGGGCGTGCCGCGGGTG 
CTGGTCCACGAAGGCCTCGGCACGCTGCTGCCGTACCGCCCGCTGCTTCGCGCCCTGGGTGAGGGGCGGCCG 
TTGCTGGGGCTGGCCGTGCATGACAGCGACGCCTACCTGGCGATCCCCGCCGAGTATCTCAACGCCTGTCTC 
GGCCGCCGCTACGCCGAGGCGCTCCATGGCGCCGGGCTGCGTGAGGTCGACCTGCTCGGCTACTGCTCCGGC 
GGGCTGGTCGCCCTGGAGACCGCCAAGTCTCTGCTCCAGCGCGGGGTGCGCGTGCGCCAGCTGGATATCGTC 
TCCAGCTACCGGATTCCCTACCGGGTGGACGACGAGCGCTTGCTGTTGTTCAGCTTCGCCGCGACCCTCGGA 
CTGGATACCGCGGCGCTCGGCTTCCCCGCGCCGGAACGTCTCGGCCAGGCGGTGCAGGCGGCGCTCGCGCAG 
ACACCGGAGCGCCTGGGCGCCGAGGCGCTGGCGGGGCTACCGGGCCTGGCCGATCTCGTCGCCCTGCGCGGC 
CGCGTGCTACAGGCGGCCAGCGGTAGTGCCGACGCCGCCAGCGTCGAACGCGACACCCTCTACCGGCTGTTC 
TGTCACTCGGTGCGTGCCAGCCAGGCCGAGGCGCTGGAGCCCTACGTCGGCGCGCTGCGGCTGTTCGTGCCG 
GACGCCGGCAACCCATTGGTGCCGCGCTACGCCGAGGCCCTGGAGACCCAATGGCGGGCCGCCGCGCTCGGC 
GCGTGCGGCATCCACGAGGTGCCCGGCGGGCACTTCGACTGCCTGGGCGAAGCCCTGGCGCAATCCCTGTCG 
AAACCCATGCCAGAGGAGGCGAGCCAATGA