ViewGene

Locus Name:
GeneID:
Location:

GeneID:63
TrivialName: PA14_38410
AnnotatorUID:
Modification Date/Time:2006-04-06 13:01:23
LocusName:PA14_38410
PAO1 Ortholog Locus:PA2018
Sequence Length:3138
Protein Length:1045
Start: 3422892
Stop: 3426029
Strand: +
Type:
ChromosomeID:2
Status: ACTIVE
Frame Discrepancy: FALSE
Missense Discrepancy:FALSE
Comments:
Homology: gb|AAG05406.1|AE004628_4 (AE004628) RND multidrug efflux transporter [Pseudomonas aeruginosa PAO1]
Identities = 1035/1045 (99%), Positives = 1040/1045 (99%)
Sequence:
ATGGCTCGTTTCTTCATTGACCGGCCGGTCTTCGCCTGGGTGATCTCCCTGCTGATCGTGCTCGCCGGGGTC
CTGGCGATCCGCTTCCTGCCGGTCGCCCAGTACCCGGACATCGCGCCGCCGGTGGTCAACGTCAGCGCCAGC
TATCCCGGCGCCTCGGCcAaggTGGTCGAGGAAGCGGTGACCGCGATCATCGAGCGCGAGATGAACGGCGCG
CCCGGCCTGCTCTACACCAagGcCACCAGCAGCACCGGCcagGCTTCGCTGACCCTGACCTTCCGCCAGGGC
GTGAACGCCGACCTCGCCGCGGTGGAAGTGCAGAACCGCCTGAAGATCGTCGAGTCGCGCCTGCCCGAGTCG
GTGCGGCGCGACGGTATCTACGTGGAgaaagcGGCGGACAGCATCCAGCTGATCGTCACCCTCACCTCCTCC
AGCGGCCGCTACGACGCCATGGAACTGGGCGAGATCgCCTCGTcCAACGTGTTGCAGGCGCTGCGCCGGGTG
GAGGGCGTGGGCAAGGTccagacctgggGCGCCGAGTACGCCATGCGCATCTGGCCCGACCCGGCCAAGCTG
ACCTCGATGAACCTCAGCGCCAGCGACCTGGTCAACGCCGTGCGCCGGCACAACGCCCGCCTCACCGTGGGC
GACATCGGCAACCTCGGGGTCCCCGACTCGGCGCCGATCAGCGCCACGGTGAAGGTCGACGACACCCTGGTG
ACGCCCGAGCAGTTCGGCGAGATTCCGCTGCGCATCCGCGCCGACGGCGGCGCGATCCGCCTGCGCGACGTG
GCCCGCGTCGAGTTCGGCCAAAGCGAGTACGGCTTCGTCTCGCGGGTCAACCAGATGACCGCCACCGGCCTG
GCGGTGAAGATGGCGCCCGGCTCCAACGCAGTGGCCACCGCCAAGCGCATCCGCGCCACCCTCGACGAGCTG
TCGCGCTACTTCCCGGAGGGCGTGAGCTACAACATCCCCTACGACACCTCGGCGTTCGTCGAGATCTCGATC
AGGAAGGTGGTCAGCACCCTGCTCGAGGCGATGCTGCTGGTGTTCGCCGTGATGTACCTGTTCATGCAGAAC
TTCCGCGCCACCCTGATCCCGACGCTGGTGGTGCCGGTGGCCCTGCTCGGCACCTTCACGGTGATGCTCGGC
CTGGGCTTCTCGATcAacGTGCTGACCATGTtcggcATGGTCCTGGCGATCGGCATCCTGGTGGAcgacgcG
ATCAtcgTggtggagaacgtcgagcggctgatggcccaagaagGCctgtcgcCgcacgACacCaCGGTCAAG
GcGATGCGCcaaaTCAGCGGGGCCATCGTCGGCATCACCGTGGTGCTGGTCTCGGTATTCGTGCCGATGGCG
TTCTTCAGCGGCGCGGTGGGCAACATCTACCGCCAGTTCGCGGTGACCCTGGCGGTCTCCATCGGCTTCTCG
GCGTTCCTCGCGCTGTCGCTGACCCCGGCCCTGTGCGCCACCCTGCTGCGCCCGATCGACGCCGACCACCAT
GAGAAGCGCGGCTTCTTCGGCTGGTTCAACCGCGCCTTCCTGCGCCTGACCGGACGCTACCGCAACGCGGTG
GCCGGCATCCTCGCCCGGCCGGTCCGCTGGATGCTGGTCTACGCCCTGGTCATCGGCGTGGTCGCCCTGCTC
TTCGTGCGCCTGCCGCAGGCGTTCCTGCCGGAAGAGGACCAGGGCGACTTCATGATCATGGTGATGCAGCCC
GAAGGCACGCCGATGGCGGAGACCATGGCCAACGTCGCCGATGTAGAGCGCTACCTGGCGGAGCACGAACCG
GTGGCCTACGCCTATGCGGTCGGCGGCTTCAGCCTGTACGGCGACGGCACCAGCTCGGCGATGATCTTCGCC
ACCCTGAAGGACTGGTCGGAACGCCGGGAGGCCAGCCAGCACGTCGGCGCCATCGTCGAGCGCATCAACCAG
CGCTTCGCCGGCCTGCCCAACCGTACGGTGTATGCGATGAACTCGCCGCCGCTGCCGGACCTGGGTTCCACC
AGCGGCTTCGACTTCCGCCTGCAGGACCGTGGCGGGGTCGGCTACGAGGCCCTGGTCAAGGCCCGCGACCAG
TTGCTGGCGCGCGCCGCCGAGGACCCGCGCCTGGCCAACGTGATGTTCGCCGGCCAGGGCGAGGCGCCGCAG
ATCCGCCTGGACATCGACCGGCGCAAGGCGGAGACCCTCGGCGTGAGCATGGACGAGATCAACACCACCCTG
GCGGTGATGTTCGGCTCGGACTACATCGGCGACTTCATGCACGGCAGCCAGGTGCGCAAGGTGGTGGTCCAG
GCCGACGGCGCCAAGCGCCTGGGCATCGACGACATCGGCCGGCTTCACGTGCGCAACGAGCAGGGCGAGATG
GTCCCGCTGGCGACGTTCGCCAAGGCCGCCTGGACCCTCGGCCCGCCGCAACTGACCCGCTACAACGGCTAT
CCCTCGTTCAACCTCGAGGGCCAGGCCGCACCGGGCTACAGCAGCGGCGAAGCCATGCAGGCGATGGAGGAA
TTGATGCAGGGCCTGCCCGAGGGCATCGCCCACGAGTGGTCCGGCCAGTCCTTCGAAGAACGCCTGTCCGGC
GCCCAGGCGCCGGCGCTGTTCGCCCTCTCGGTGCTGATCGTGTTCCTCGCCCTGGCCGCCCTCTACGAAAGC
TGGTCGATCCCGCTGGCGGTGATCCTGGTGGTGCCGCTGGGCGTGCTCGGCGCACTGCACGGGGTGAGCCTG
CGCGGCCTGCCCAACGACATCTACTTCAAGGTCGGCCTGATCACCATCATCGGCCTCTCGGCGAAGAACGCC
ATCCTCATCATCGAGGTAGCCAAGGACCATTACCAGGAAGGCATGAGCCTGCTGCAGGCGACCCTGGAGGCC
GCGCGCCTGCGCCTGCGACCGATCGTCATGACCTCGCTGGCGTTCGGTTTCGGCGTGGTCCCGCTGGCGCTC
TCCAGCGGCGCCGGTTCCGGCGCCCAGGTCGCCATCGGCACCGGGGTGCTCGGCGGGATCGTCACCGCCACG
GTACTCGCGGTGTTCCTGGTACCGCTGTTCTTCCTGGTGGTCGGGCGCCTGTTCCGGTTACGCAAGGCGCCG
CGCACCGGCACCTCGCCCCGGATCCCGACGGAGCAAGCCTGA
Translation:
MARFFIDRPVFAWVISLLIVLAGVLAIRFLPVAQYPDIAPPVVNVSASYPGASAKVVEEAVTAIIEREMNGA
PGLLYTKATSSTGQASLTLTFRQGVNADLAAVEVQNRLKIVESRLPESVRRDGIYVEKAADSIQLIVTLTSS
SGRYDAMELGEIASSNVLQALRRVEGVGKVQTWGAEYAMRIWPDPAKLTSMNLSASDLVNAVRRHNARLTVG
DIGNLGVPDSAPISATVKVDDTLVTPEQFGEIPLRIRADGGAIRLRDVARVEFGQSEYGFVSRVNQMTATGL
AVKMAPGSNAVATAKRIRATLDELSRYFPEGVSYNIPYDTSAFVEISIRKVVSTLLEAMLLVFAVMYLFMQN
FRATLIPTLVVPVALLGTFTVMLGLGFSINVLTMFGMVLAIGILVDDAIIVVENVERLMAQEGLSPHDTTVK
AMRQISGAIVGITVVLVSVFVPMAFFSGAVGNIYRQFAVTLAVSIGFSAFLALSLTPALCATLLRPIDADHH
EKRGFFGWFNRAFLRLTGRYRNAVAGILARPVRWMLVYALVIGVVALLFVRLPQAFLPEEDQGDFMIMVMQP
EGTPMAETMANVADVERYLAEHEPVAYAYAVGGFSLYGDGTSSAMIFATLKDWSERREASQHVGAIVERINQ
RFAGLPNRTVYAMNSPPLPDLGSTSGFDFRLQDRGGVGYEALVKARDQLLARAAEDPRLANVMFAGQGEAPQ
IRLDIDRRKAETLGVSMDEINTTLAVMFGSDYIGDFMHGSQVRKVVVQADGAKRLGIDDIGRLHVRNEQGEM
VPLATFAKAAWTLGPPQLTRYNGYPSFNLEGQAAPGYSSGEAMQAMEELMQGLPEGIAHEWSGQSFEERLSG
AQAPALFALSVLIVFLALAALYESWSIPLAVILVVPLGVLGALHGVSLRGLPNDIYFKVGLITIIGLSAKNA
ILIIEVAKDHYQEGMSLLQATLEAARLRLRPIVMTSLAFGFGVVPLALSSGAGSGAQVAIGTGVLGGIVTAT
VLAVFLVPLFFLVVGRLFRLRKAPRTGTSPRIPTEQA*
AnnotationID:73GeneID:63
AnnotatorUID: diggins
Modification Date/Time: 2005-03-02 20:08:43
Gene Name:amrB
Confidence Code:2
GeneProduct:RND multidrug efflux transporter
Cell Localization:()
Synonyms:mexH
Cell Localization Confidence Code:5
MolecularFunction:transmembrane efflux pump protein
Functional Category:(3) Antibiotic resistance and susceptibility
Alternate Gene Product Name:
Functional Category Confidence Code:5
COGs:pfam00873,COG0841,COG3696
Secondary Functional Category(ies):transport of small molecules
EC Number:
Status:ACTIVE
Pathway:
Homology:
>emb|CAD85023.1| (BX321859) RND multidrug efflux transporter [Nitrosomonas europaea
            ATCC 19718]
          Length = 1033

 Score = 1465 bits (3792), Expect = 0.0
 Identities = 736/1028 (71%), Positives = 865/1028 (84%), Gaps = 1/1028 (0%)

>gb|AAC27754.1| (AF072887) putative transporter AmrB [Burkholderia pseudomallei]
          Length = 1043

 Score = 1451 bits (3755), Expect = 0.0
 Identities = 724/1026 (70%), Positives = 853/1026 (83%)

>gb|AAL44018.1| (AE009250) RND multidrug efflux transporter [Agrobacterium
            tumefaciens str. C58 (U. Washington)]
          Length = 1044

 Score = 1094 bits (2829), Expect = 0.0
 Identities = 556/1031 (53%), Positives = 739/1031 (71%), Gaps = 2/1031 (0%)
Structural Features:
pfam00873, ACR_tran, AcrB/AcrD/AcrF family.
CD-Length = 1017 residues,  99.9% aligned
Score = 1053 bits (2724), Expect = 0.0
Identities = 480/1026 (46%), Positives = 668/1026 (65%), Gaps = 14/1026 (1%)

COG0841, AcrB, Cation/multidrug efflux pump [Defense mechanisms]
CD-Length = 1009 residues,  99.9% aligned
Score =  994 bits (2571), Expect = 0.0
Identities = 524/1030 (50%), Positives = 711/1030 (69%), Gaps = 27/1030 (2%)

COG3696, COG3696, Putative silver efflux pump 
[Inorganic ion transport and metabolism
CD-Length = 1027 residues,  99.6% aligned
Score =  452 bits (1164), Expect = 1e-127
Identities = 281/1067 (26%), Positives = 496/1067 (46%), Gaps = 79/1067 (7%)
Genomic Context:
Comment:
ReferenceID:129
Author/Investigator(s): GenNotator
Title:
PubMed:
MedLine:
Source:
Reference Type:BLASTP
Data:
URL:
ReferenceID:17271
Author/Investigator(s): GenNotator
Title: CDD Search
PubMed:
MedLine:
Source:
Reference Type:RPSBLAST
Data:
URL:
ReferenceID:32696
Author/Investigator(s):
Title: CDD Search
PubMed:
MedLine:
Source:
Reference Type:Misc (text/plain)
Data:63_cdd.html
URL:
ReferenceID:34386
Author/Investigator(s): Westbrock-Wadman S, Sherman DR, Hickey MJ, Coulter SN, Zhu YQ, Warrener P, Nguyen LY, Shawar RM, Folger KR, Stover CK.
Title: Characterization of a Pseudomonas aeruginosa efflux pump contributing to aminoglycoside impermeability.
PubMed: 10582892
MedLine:
Source:
Antimicrob Agents Chemother. 1999 Dec;43(12):2975-83.
Reference Type:Journal
Data:
URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10582892
Homologs By Global Alignment
Gene ID:63

Identity:

0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%
HomologID Accession Description Length PctIdentity PctSimilarity Gaps Score
122 PA2018_tr translation of PA2018 1045 99.04 99.52 0 5166.0
12846 gb|AAF14523.1|AF147719_3 (AF147719) putative RND transporter; AmrB [Pseudomonas aeruginosa] 1045 99.04 99.52 0 5166.0
12845 gb|AAG05406.1|AE004628_4 (AE004628) RND multidrug efflux transporter [Pseudomonas aeruginosa PAO1] 1045 99.04 99.52 0 5166.0
12847 gb|AAC64522.1| (AF073776) transmembrane efflux pump protein [Pseudomonas aeruginosa] 1045 97.79 98.46 1 5084.0
12848 dbj|BAA34300.1| (AB015853) MexY [Pseudomonas aeruginosa] 1059 92.06 93.10 27 4758.0
GC ORFID: 43065How Found: BLASTX
GC_TrimmedSeqID: 69Blast Result ID
Subject Sequence Name: t_PA2018Glimmer Score:
Start: 1531019Stop: 1527882
Length: 3138
Start Codon: ATGTruncated Start:
Stop Codon: TGATruncated Stop:
Homolog: t_PA2018 translation of PA2018Homolog Bit Score 1994.0
Other Homologs: t_PA4598 (ORF: BLASTX 1052.0), t_PA0426 (ORF: BLASTX 1013.0), psyr_15may02_Scaffold5_revised_gene6178 (ORF: BLASTX 983.0), t_PA2494 (ORF: BLASTX 800.0), psyr_15may02_Scaffold7_revised_gene7199 (ORF: BLASTX 798.0), t_PA3522 (ORF: BLASTX 749.0), psyr_15may02_Scaffold7_revised_gene7337 (ORF: BLASTX 127.0), t_PA2018 (ORF: GLIMMER)
GC ORF Sequence
ATGGCTCGTTTCTTCATTGACCGGCCGGTCTTCGCCTGGGTGATCTCCCTGCTGATCGTGCTCGCCGGGGTC
CTGGCGATCCGCTTCCTGCCGGTCGCCCAGTACCCGGACATCGCGCCGCCGGTGGTCAACGTCAGCGCCAGC
TATCCCGGCGCCTCGGCcAaggTGGTCGAGGAAGCGGTGACCGCGATCATCGAGCGCGAGATGAACGGCGCG
CCCGGCCTGCTCTACACCAagGcCACCAGCAGCACCGGCcagGCTTCGCTGACCCTGACCTTCCGCCAGGGC
GTGAACGCCGACCTCGCCGCGGTGGAAGTGCAGAACCGCCTGAAGATCGTCGAGTCGCGCCTGCCCGAGTCG
GTGCGGCGCGACGGTATCTACGTGGAgaaagcGGCGGACAGCATCCAGCTGATCGTCACCCTCACCTCCTCC
AGCGGCCGCTACGACGCCATGGAACTGGGCGAGATCgCCTCGTcCAACGTGTTGCAGGCGCTGCGCCGGGTG
GAGGGCGTGGGCAAGGTccagacctgggGCGCCGAGTACGCCATGCGCATCTGGCCCGACCCGGCCAAGCTG
ACCTCGATGAACCTCAGCGCCAGCGACCTGGTCAACGCCGTGCGCCGGCACAACGCCCGCCTCACCGTGGGC
GACATCGGCAACCTCGGGGTCCCCGACTCGGCGCCGATCAGCGCCACGGTGAAGGTCGACGACACCCTGGTG
ACGCCCGAGCAGTTCGGCGAGATTCCGCTGCGCATCCGCGCCGACGGCGGCGCGATCCGCCTGCGCGACGTG
GCCCGCGTCGAGTTCGGCCAAAGCGAGTACGGCTTCGTCTCGCGGGTCAACCAGATGACCGCCACCGGCCTG
GCGGTGAAGATGGCGCCCGGCTCCAACGCAGTGGCCACCGCCAAGCGCATCCGCGCCACCCTCGACGAGCTG
TCGCGCTACTTCCCGGAGGGCGTGAGCTACAACATCCCCTACGACACCTCGGCGTTCGTCGAGATCTCGATC
AGGAAGGTGGTCAGCACCCTGCTCGAGGCGATGCTGCTGGTGTTCGCCGTGATGTACCTGTTCATGCAGAAC
TTCCGCGCCACCCTGATCCCGACGCTGGTGGTGCCGGTGGCCCTGCTCGGCACCTTCACGGTGATGCTCGGC
CTGGGCTTCTCGATcAacGTGCTGACCATGTtcggcATGGTCCTGGCGATCGGCATCCTGGTGGAcgacgcG
ATCAtcgTggtggagaacgtcgagcggctgatggcccaagaagGCctgtcgcCgcacgACacCaCGGTCAAG
GcGATGCGCcaaaTCAGCGGGGCCATCGTCGGCATCACCGTGGTGCTGGTCTCGGTATTCGTGCCGATGGCG
TTCTTCAGCGGCGCGGTGGGCAACATCTACCGCCAGTTCGCGGTGACCCTGGCGGTCTCCATCGGCTTCTCG
GCGTTCCTCGCGCTGTCGCTGACCCCGGCCCTGTGCGCCACCCTGCTGCGCCCGATCGACGCCGACCACCAT
GAGAAGCGCGGCTTCTTCGGCTGGTTCAACCGCGCCTTCCTGCGCCTGACCGGACGCTACCGCAACGCGGTG
GCCGGCATCCTCGCCCGGCCGGTCCGCTGGATGCTGGTCTACGCCCTGGTCATCGGCGTGGTCGCCCTGCTC
TTCGTGCGCCTGCCGCAGGCGTTCCTGCCGGAAGAGGACCAGGGCGACTTCATGATCATGGTGATGCAGCCC
GAAGGCACGCCGATGGCGGAGACCATGGCCAACGTCGCCGATGTAGAGCGCTACCTGGCGGAGCACGAACCG
GTGGCCTACGCCTATGCGGTCGGCGGCTTCAGCCTGTACGGCGACGGCACCAGCTCGGCGATGATCTTCGCC
ACCCTGAAGGACTGGTCGGAACGCCGGGAGGCCAGCCAGCACGTCGGCGCCATCGTCGAGCGCATCAACCAG
CGCTTCGCCGGCCTGCCCAACCGTACGGTGTATGCGATGAACTCGCCGCCGCTGCCGGACCTGGGTTCCACC
AGCGGCTTCGACTTCCGCCTGCAGGACCGTGGCGGGGTCGGCTACGAGGCCCTGGTCAAGGCCCGCGACCAG
TTGCTGGCGCGCGCCGCCGAGGACCCGCGCCTGGCCAACGTGATGTTCGCCGGCCAGGGCGAGGCGCCGCAG
ATCCGCCTGGACATCGACCGGCGCAAGGCGGAGACCCTCGGCGTGAGCATGGACGAGATCAACACCACCCTG
GCGGTGATGTTCGGCTCGGACTACATCGGCGACTTCATGCACGGCAGCCAGGTGCGCAAGGTGGTGGTCCAG
GCCGACGGCGCCAAGCGCCTGGGCATCGACGACATCGGCCGGCTTCACGTGCGCAACGAGCAGGGCGAGATG
GTCCCGCTGGCGACGTTCGCCAAGGCCGCCTGGACCCTCGGCCCGCCGCAACTGACCCGCTACAACGGCTAT
CCCTCGTTCAACCTCGAGGGCCAGGCCGCACCGGGCTACAGCAGCGGCGAAGCCATGCAGGCGATGGAGGAA
TTGATGCAGGGCCTGCCCGAGGGCATCGCCCACGAGTGGTCCGGCCAGTCCTTCGAAGAACGCCTGTCCGGC
GCCCAGGCGCCGGCGCTGTTCGCCCTCTCGGTGCTGATCGTGTTCCTCGCCCTGGCCGCCCTCTACGAAAGC
TGGTCGATCCCGCTGGCGGTGATCCTGGTGGTGCCGCTGGGCGTGCTCGGCGCACTGCACGGGGTGAGCCTG
CGCGGCCTGCCCAACGACATCTACTTCAAGGTCGGCCTGATCACCATCATCGGCCTCTCGGCGAAGAACGCC
ATCCTCATCATCGAGGTAGCCAAGGACCATTACCAGGAAGGCATGAGCCTGCTGCAGGCGACCCTGGAGGCC
GCGCGCCTGCGCCTGCGACCGATCGTCATGACCTCGCTGGCGTTCGGTTTCGGCGTGGTCCCGCTGGCGCTC
TCCAGCGGCGCCGGTTCCGGCGCCCAGGTCGCCATCGGCACCGGGGTGCTCGGCGGGATCGTCACCGCCACG
GTACTCGCGGTGTTCCTGGTACCGCTGTTCTTCCTGGTGGTCGGGCGCCTGTTCCGGTTACGCAAGGCGCCG
CGCACCGGCACCTCGCCCCGGATCCCGACGGAGCAAGCCTGA