ViewGene
Locus Name:
GeneID:
Location:

GeneID:5049
TrivialName: PA14_66950
AnnotatorUID:
Modification Date/Time:2006-04-06 13:01:23
LocusName:PA14_66950
PAO1 Ortholog Locus:PA5067
Sequence Length:336
Protein Length:111
Start: 5977575
Stop: 5977910
Strand: +
Type:
ChromosomeID:2
Status: ACTIVE
Frame Discrepancy: FALSE
Missense Discrepancy:FALSE
Comments:
Homology: gb|AAG08452.1|AE004920_2 (AE004920) phosphoribosyl-ATP pyrophosphohydrolase [Pseudomonas aeruginosa PAO1]
Identities = 110/111 (99%), Positives = 110/111 (99%)
Sequence:
ATGAGTGACACCCTGACCCGTCTGGCGGCGGTGCTTGAGGAGCGCAAGAACGCCGCGCCCGACAGCTCCTAC
GTGGCCAGCCTGTACCACAAGGGCCTGAACAAGATCCTGGAGAAGGTCGGCGAGGAGTCGGTGGAAGCCATC
ATCGCCGCCAAGGATGCCGCGGCCAGCGGCGACTGCCAGGACCTGATCTACGAAACCGCCGACCTCTGGTTC
CACTCGCTGGTGATGCTCTCGGCCCTCGGCCAGCATCCGCAAGCCGTGCTGGACGAACTGGAGCGCCGCTTC
GGTCTTTCCGGCCACGCCGAGAAAGCCGCCCGCCAACCATCGGCCTGA
Translation:
MSDTLTRLAAVLEERKNAAPDSSYVASLYHKGLNKILEKVGEESVEAIIAAKDAAASGDCQDLIYETADLWF
HSLVMLSALGQHPQAVLDELERRFGLSGHAEKAARQPSA*
AnnotationID:5054GeneID:5049
AnnotatorUID: diggins
Modification Date/Time: 2005-04-26 12:12:22
Gene Name:hisE
Confidence Code:2
GeneProduct:phosphoribosyl-ATP pyrophosphohydrolase
Cell Localization:()
Synonyms:
Cell Localization Confidence Code:5
MolecularFunction:
Functional Category:(8) Central intermediary metabolism
Alternate Gene Product Name:
Functional Category Confidence Code:5
COGs:pfam01503,COG0140
Secondary Functional Category(ies):amino acid biosynthesis and metabolims
EC Number:3.6.1.39
Status:ACTIVE
Pathway:






 
Homology:
>gb|AAN70580.1|AE016700_8 (AE016792) phosphoribosyl-ATP pyrophosphatase [Pseudomonas putida
           KT2440]
          Length = 111

 Score =  192 bits (488), Expect = 3e-49
 Identities = 99/111 (89%), Positives = 101/111 (90%)

>gb|AAO58580.1| (AE016874) phosphoribosyl-ATP pyrophosphatase [Pseudomonas syringae
           pv. tomato str. DC3000]
          Length = 110

 Score =  186 bits (472), Expect = 2e-47
 Identities = 91/107 (85%), Positives = 100/107 (93%)

>emb|CAD16651.1| (AL646072) PROBABLE PHOSPHORIBOSYL-ATP PYROPHOSPHATASE PROTEIN
           [Ralstonia solanacearum]
          Length = 124

 Score =  110 bits (275), Expect = 2e-24
 Identities = 61/118 (51%), Positives = 80/118 (67%), Gaps = 7/118 (5%)








 
Structural Features:
pfam01503, PRA-PH, Phosphoribosyl-ATP pyrophosphohydrolase. This enzyme catalyses 
the second step in the histidine biosynthetic pathway.
CD-Length = 89 residues, 100.0% aligned
Score =  106 bits (265), Expect = 8e-25
Identities = 47/93 (50%), Positives = 62/93 (66%), Gaps = 4/93 (4%)

COG0140, HisI, Phosphoribosyl-ATP pyrophosphohydrolase 
[Amino acid transport and metabolism]
CD-Length = 92 residues,  98.9% aligned
Score =  103 bits (258), Expect = 5e-24
Identities = 49/95 (51%), Positives = 66/95 (69%), Gaps = 4/95 (4%)






   
Genomic Context:






   
Comment:


















    ReferenceID:10098




  
Author/Investigator(s):
        GenNotator





  
Title:
        




  
PubMed:
        


MedLine:
        




    
Source:






    
Reference Type:BLASTP 







    
Data:


    		




 
URL:

















    ReferenceID:27239




  
Author/Investigator(s):
        GenNotator





  
Title:
        CDD Search




  
PubMed:
        


MedLine:
        




    
Source:






    
Reference Type:RPSBLAST 







    
Data:


    		




 
URL:

















    ReferenceID:35031




  
Author/Investigator(s):
        





  
Title:
        CDD Search




  
PubMed:
        


MedLine:
        




    
Source:






    
Reference Type:Misc (text/plain)







    
Data:5049_cdd.html


    		




 
URL:

















    ReferenceID:35824




  
Author/Investigator(s):
        Kwon JH, Chun JY, Lee HS, Cheon CI, Song ES, Min KH, Lee MS.





  
Title:
        Cloning of the histidine biosynthetic genes from Corynebacterium glutamicum: organization and analysis of the hisG and hisE genes.




  
PubMed:
        11006846


MedLine:
        




    
Source:
Can J Microbiol. 2000 Sep;46(9):848-55.






    
Reference Type:Journal 







    
Data:


    		




 
URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11006846









           
Homologs By Global Alignment 

           

       



     
Gene ID:5049
           
Identity:

                               
                                   0%
                               
                                   10%
                               
                                   20%
                               
                                   30%
                               
                                   40%
                               
                                   50%
                               
                                   60%
                               
                                   70%
                               
                                   80%
                               
                                   90%
                               
                                   100%
                               
                             

                           

     
HomologID
                           Accession
                           Description
                           Length
                           PctIdentity
                           PctSimilarity
                           Gaps
                           Score
     

     
     
7456
                           PA5067_tr
                           translation of PA5067
                           111
                           99.09
                           99.09
                           0
                           550.0
     

     
     
192758
                           gb|AAG08452.1|AE004920_2
                           (AE004920) phosphoribosyl-ATP pyrophosphohydrolase [Pseudomonas aeruginosa PAO1]
                           111
                           99.09
                           99.09
                           0
                           550.0
     

     
     
192759
                           gb|AAA92107.1|
                           (U48404) ORF3; similar to the C-terminal of phosphoribosyl c-AMP hydrolase [Azotobacter chroococcum]
                           111
                           89.18
                           92.79
                           1
                           498.0
     

     
     
192760
                           gb|AAN70580.1|AE016700_8
                           (AE016792) phosphoribosyl-ATP pyrophosphatase [Pseudomonas putida KT2440]
                           111
                           89.18
                           90.99
                           0
                           488.0
     

     
     
192761
                           gb|AAO58580.1|
                           (AE016874) phosphoribosyl-ATP pyrophosphatase [Pseudomonas syringae pv. tomato str. DC3000]
                           111
                           81.98
                           90.09
                           1
                           470.0
     

     






      

          
GC ORFID: 48051How Found: BLASTX

          
GC_TrimmedSeqID: 69Blast Result ID

          
Subject Sequence Name: t_PA5067Glimmer Score: 

          
Start: 5241259Stop: 5241594

          
Length: 336


          
Start Codon: ATGTruncated Start:

          
Stop Codon: TGATruncated Stop: 

          
Homolog: t_PA5067 translation of PA5067Homolog Bit Score 216.0

          
Other Homologs:  psyr_15may02_Scaffold2_revised_gene3798 (ORF: BLASTX 186.0), t_PA5067 (ORF: GLIMMER)

          
GC ORF Sequence

           
ATGAGTGACACCCTGACCCGTCTGGCGGCGGTGCTTGAGGAGCGCAAGAACGCCGCGCCCGACAGCTCCTAC 
GTGGCCAGCCTGTACCACAAGGGCCTGAACAAGATCCTGGAGAAGGTCGGCGAGGAGTCGGTGGAAGCCATC 
ATCGCCGCCAAGGATGCCGCGGCCAGCGGCGACTGCCAGGACCTGATCTACGAAACCGCCGACCTCTGGTTC 
CACTCGCTGGTGATGCTCTCGGCCCTCGGCCAGCATCCGCAAGCCGTGCTGGACGAACTGGAGCGCCGCTTC 
GGTCTTTCCGGCCACGCCGAGAAAGCCGCCCGCCAACCATCGGCCTGA