ViewGene
Locus Name:
GeneID:
Location:

GeneID:4909
TrivialName: PA14_19620
AnnotatorUID:
Modification Date/Time:2006-04-06 13:01:23
LocusName:PA14_19620
PAO1 Ortholog Locus:PA3439
Sequence Length:372
Protein Length:123
Start: 1694713
Stop: 1694342
Strand: -
Type:
ChromosomeID:2
Status: ACTIVE
Frame Discrepancy: FALSE
Missense Discrepancy:FALSE
Comments:
Homology: gb|AAG06827.1|AE004764_13 (AE004764) d-erythro-7,8-dihydroneopterin triphosphate epimerase [Pseudomonas aeruginosa PAO1]
Identities = 123/123 (100%), Positives = 123/123 (100%)
Sequence:
ATGCCGCGACTGGAACCGGGAATGGCGCGAATCCGCGTCAAGGACCTGCGCCTGCGCACCTTCATCGGGATC
AAGGAGGAGGAAATCCTCAACAAGCAGGACGTGCTGATCAACCTGACCATCCTCTACCCGGCCGCGGACGCC
GTGGAGGTCAACGACATCGAGCACGCGCTGAACTACCGCACCATCACCAAGGCGATCATCCGCCACGTCGAG
GAGAACCGCTTCGCCCTGCTCGAACGGATGACCCAGGAAATCCTCGACCTGGTGATGGAGAACCCGGCGGTG
CGCTACGCCGAGGTGGAAGTGGACAAGCCGCACGCGCTGCGCTTCGCCGAGTCGGTCTCGATCACCCTCGCC
GGCCACCGCTGA
Translation:
MPRLEPGMARIRVKDLRLRTFIGIKEEEILNKQDVLINLTILYPAADAVEVNDIEHALNYRTITKAIIRHVE
ENRFALLERMTQEILDLVMENPAVRYAEVEVDKPHALRFAESVSITLAGHR*
AnnotationID:4914GeneID:4909
AnnotatorUID: diggins
Modification Date/Time: 2005-04-18 18:06:38
Gene Name:folX
Confidence Code:2
GeneProduct:D-erythro-7,8-dihydroneopterin triphosphate epimerase
Cell Localization:()
Synonyms:folB
Cell Localization Confidence Code:5
MolecularFunction:
Functional Category:(4) Biosynthesis of cofactors, prosthetic groups and carriers
Alternate Gene Product Name:dihydroneopterin aldolase
Functional Category Confidence Code:5
COGs:cd00534,pfam02152,COG1539
Secondary Functional Category(ies):
EC Number:4.1.2.25
Status:ACTIVE
Pathway:






 
Homology:
>gb|AAO54708.1| (AE016860) dihydroneopterin aldolase [Pseudomonas syringae pv.
           tomato str. DC3000]
          Length = 123

 Score =  201 bits (511), Expect = 6e-52
 Identities = 104/123 (84%), Positives = 111/123 (90%)

>gb|AAP17710.1| (AE016986) D-erythro-7,8-dihydroneopterin triphosphate epimerase
           [Shigella flexneri 2a str. 2457T]
          Length = 120

 Score =  147 bits (370), Expect = 1e-35
 Identities = 74/115 (64%), Positives = 94/115 (81%)

>gb|AAC75363.1| (AE000319) D-erythro-7,8-dihydroneopterin tri P epimerase
           [Escherichia coli K12]
          Length = 120

 Score =  147 bits (370), Expect = 1e-35
 Identities = 74/115 (64%), Positives = 94/115 (81%)








 
Structural Features:
cd00534, DHNA_DHNTPE, Dihydroneopterin aldolase (DHNA) 
and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE)
CD-Length = 118 residues,  97.5% aligned
Score = 93.4 bits (232), Expect = 6e-21
Identities = 41/115 (35%), Positives = 68/115 (59%), Gaps = 3/115 (2%)

pfam02152, FolB, Dihydroneopterin aldolase
CD-Length = 112 residues,  99.1% aligned
Score = 93.3 bits (232), Expect = 7e-21
Identities = 40/111 (36%), Positives = 68/111 (61%), Gaps = 1/111 (0%)

COG1539, FolB, Dihydroneopterin aldolase [Coenzyme metabolism]
CD-Length = 121 residues,  96.7% aligned
Score =  104 bits (260), Expect = 4e-24
Identities = 40/117 (34%), Positives = 64/117 (54%), Gaps = 1/117 (0%)







   
Genomic Context:






   
Comment:


















    ReferenceID:9818




  
Author/Investigator(s):
        GenNotator





  
Title:
        




  
PubMed:
        


MedLine:
        




    
Source:






    
Reference Type:BLASTP 







    
Data:


    		




 
URL:

















    ReferenceID:26959




  
Author/Investigator(s):
        GenNotator





  
Title:
        CDD Search




  
PubMed:
        


MedLine:
        




    
Source:






    
Reference Type:RPSBLAST 







    
Data:


    		




 
URL:

















    ReferenceID:32129




  
Author/Investigator(s):
        





  
Title:
        CDD Search




  
PubMed:
        


MedLine:
        




    
Source:






    
Reference Type:Misc (text/plain)







    
Data:4909_cdd.html


    		




 
URL:

















    ReferenceID:34087




  
Author/Investigator(s):
        Haussmann C, Rohdich F, Schmidt E, Bacher A, Richter G.





  
Title:
        Biosynthesis of pteridines in Escherichia coli. Structural and mechanistic similarity of dihydroneopterin-triphosphate epimerase and dihydroneopterin aldolase.




  
PubMed:
        9651328


MedLine:
        




    
Source:
J Biol Chem. 1998 Jul 10;273(28):17418-24.






    
Reference Type:Journal 







    
Data:


    		




 
URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9651328









           
Homologs By Global Alignment 

           

       



     
Gene ID:4909
           
Identity:

                               
                                   0%
                               
                                   10%
                               
                                   20%
                               
                                   30%
                               
                                   40%
                               
                                   50%
                               
                                   60%
                               
                                   70%
                               
                                   80%
                               
                                   90%
                               
                                   100%
                               
                             

                           

     
HomologID
                           Accession
                           Description
                           Length
                           PctIdentity
                           PctSimilarity
                           Gaps
                           Score
     

     
     
7312
                           PA3439_tr
                           translation of PA3439
                           123
                           99.99
                           99.99
                           0
                           611.0
     

     
     
190329
                           gb|AAG06827.1|AE004764_13
                           (AE004764) d-erythro-7,8-dihydroneopterin triphosphate epimerase [Pseudomonas aeruginosa PAO1]
                           123
                           99.99
                           99.99
                           0
                           611.0
     

     
     
190330
                           gb|AAO54708.1|
                           (AE016860) dihydroneopterin aldolase [Pseudomonas syringae pv. tomato str. DC3000]
                           123
                           84.55
                           90.24
                           0
                           511.0
     

     
     
190339
                           dbj|BAA16140.1|
                           (D90861) similar to [SwissProt Accession Number P31055] [Escherichia coli]
                           127
                           59.05
                           75.59
                           11
                           367.0
     

     
     
190338
                           dbj|BAA16149.1|
                           (D90862) similar to [SwissProt Accession Number P31055] [Escherichia coli]
                           127
                           59.05
                           75.59
                           11
                           367.0
     

     






      

          
GC ORFID: 47911How Found: BLASTX

          
GC_TrimmedSeqID: 69Blast Result ID

          
Subject Sequence Name: t_PA3439Glimmer Score: 

          
Start: 3259219Stop: 3259590

          
Length: 372


          
Start Codon: ATGTruncated Start:

          
Stop Codon: TGATruncated Stop: 

          
Homolog: t_PA3439 translation of PA3439Homolog Bit Score 239.0

          
Other Homologs:  psyr_15may02_Scaffold3_revised_gene5035 (ORF: BLASTX 202.0), t_PA3439 (ORF: GLIMMER)

          
GC ORF Sequence

           
ATGCCGCGACTGGAACCGGGAATGGCGCGAATCCGCGTCAAGGACCTGCGCCTGCGCACCTTCATCGGGATC 
AAGGAGGAGGAAATCCTCAACAAGCAGGACGTGCTGATCAACCTGACCATCCTCTACCCGGCCGCGGACGCC 
GTGGAGGTCAACGACATCGAGCACGCGCTGAACTACCGCACCATCACCAAGGCGATCATCCGCCACGTCGAG 
GAGAACCGCTTCGCCCTGCTCGAACGGATGACCCAGGAAATCCTCGACCTGGTGATGGAGAACCCGGCGGTG 
CGCTACGCCGAGGTGGAAGTGGACAAGCCGCACGCGCTGCGCTTCGCCGAGTCGGTCTCGATCACCCTCGCC 
GGCCACCGCTGA