ViewGene
Locus Name:
GeneID:
Location:

GeneID:3796
TrivialName: PA14_41830
AnnotatorUID:
Modification Date/Time:2006-04-06 13:01:23
LocusName:PA14_41830
PAO1 Ortholog Locus:PA1757
Sequence Length:618
Protein Length:205
Start: 3738043
Stop: 3737426
Strand: -
Type:
ChromosomeID:2
Status: ACTIVE
Frame Discrepancy: FALSE
Missense Discrepancy:FALSE
Comments:
Homology: gb|AAG05146.1|AE004601_11 (AE004601) homoserine kinase [Pseudomonas aeruginosa PAO1]
Identities = 204/205 (99%), Positives = 205/205 (100%)
Sequence:
GTGGAAATTGCCTGTCTTGACCTGGAAGGCGTGCTGGTTCCGGAAATCTGGATCGCGTTCGCGGAAAAAACC
GGTATCGACGCCTTGAAGGCGACCACCCGGGACATTCCGGACTACGACGTGCTGATGAAGCAGCGCCTGCGC
ATTCTCGACGAACATGGCCTGAAGCTGGGCGATATCCAGGAGGTGATCGCCACCCTGAAGCCGCTGGAGGGG
GCGGTGGAATTCGTCGACTGGCTGCGCGAGCGCTTCCAGGTGGTGATCCTCTCCGACACCTTCTACGAGTTC
TCCCAGCCGCTGATGCGCCAGCTGGGCTTCCCGACCCTGTTGTGCCACAAGCTGGAGATCGACGACAGCGAC
CGGGTGGTCGGCTATCGATTGCGCCAGAAGGATCCCAAGCGGCAGTCGGTGATCGCCTTCAAGAGCCTCTAC
TACCGGGTGATCGCCGCAGGCGACTCCTACAACGACACCACCATGCTTTCCGAGGCCCACGCCGGCATCCTG
TTCCATGCCCCGGAAAACGTGATCCGCGAGTTTCCCCAGTTCCCCGCGGTGCATACCTACGAAGACCTCAAG
CGCGAGTTCCTCAAGGCTTCCAGCCGTTCGCTGAGCCTGTAG
Translation:
MEIACLDLEGVLVPEIWIAFAEKTGIDALKATTRDIPDYDVLMKQRLRILDEHGLKLGDIQEVIATLKPLEG
AVEFVDWLRERFQVVILSDTFYEFSQPLMRQLGFPTLLCHKLEIDDSDRVVGYRLRQKDPKRQSVIAFKSLY
YRVIAAGDSYNDTTMLSEAHAGILFHAPENVIREFPQFPAVHTYEDLKREFLKASSRSLSL*
AnnotationID:3803GeneID:3796
AnnotatorUID: diggins
Modification Date/Time: 2005-03-01 07:07:59
Gene Name:thrH
Confidence Code:1
GeneProduct:homoserine kinase
Cell Localization:()
Synonyms:
Cell Localization Confidence Code:5
MolecularFunction:
Functional Category:(2) Amino acid biosynthesis and metabolism
Alternate Gene Product Name:phosphoserine phosphatase
Functional Category Confidence Code:5
COGs:COG0560
Secondary Functional Category(ies):
EC Number:
Status:ACTIVE
Pathway:






 
Homology:
>gb|AAO55795.1| (AE016864) hydrolase, haloacid dehalogenase-like family
           [Pseudomonas syringae pv. tomato str. DC3000]
          Length = 237

 Score =  366 bits (940), Expect = e-101
 Identities = 178/205 (86%), Positives = 196/205 (95%)






 
Structural Features:
COG0560, SerB, Phosphoserine phosphatase 
[Amino acid transport and metabolism]
CD-Length = 212 residues,  96.7% aligned
Score =  105 bits (262), Expect = 5e-24
Identities = 52/205 (25%), Positives = 80/205 (39%), Gaps = 12/205 (5%)






   
Genomic Context:






   
Comment:


















    ReferenceID:14925




  
Author/Investigator(s):
        GenNotator





  
Title:
        




  
PubMed:
        


MedLine:
        




    
Source:






    
Reference Type:BLASTP 







    
Data:


    		




 
URL:

















    ReferenceID:24737




  
Author/Investigator(s):
        GenNotator





  
Title:
        CDD Search




  
PubMed:
        


MedLine:
        




    
Source:






    
Reference Type:RPSBLAST 







    
Data:


    		




 
URL:

















    ReferenceID:37169




  
Author/Investigator(s):
        





  
Title:
        CDD Search




  
PubMed:
        


MedLine:
        




    
Source:






    
Reference Type:Misc (text/plain)







    
Data:3796_cdd.html


    		




 
URL:

















    ReferenceID:37830




  
Author/Investigator(s):
        Singh SK, Yang K, Karthikeyan S, Huynh T, Zhang X, Phillips MA, Zhang H.





  
Title:
        The thrH gene product of Pseudomonas aeruginosa is a dual activity enzyme with a novel phosphoserine:homoserine phosphotransferase activity.




  
PubMed:
        14699121


MedLine:
        




    
Source:
J Biol Chem. 2004 Mar 26;279(13):13166-73. Epub 2003 Dec 29.






    
Reference Type:Journal 







    
Data:


    		




 
URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14699121

















    ReferenceID:37831




  
Author/Investigator(s):
        Patte JC, Clepet C, Bally M, Borne F, Mejean V, Foglino M.





  
Title:
        ThrH, a homoserine kinase isozyme with in vivo phosphoserine phosphatase activity in Pseudomonas aeruginosa.




  
PubMed:
        10220164


MedLine:
        




    
Source:
Microbiology. 1999 Apr;145 ( Pt 4):845-53.






    
Reference Type:Journal 







    
Data:


    		




 
URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10220164









           
Homologs By Global Alignment 

           

       



     
Gene ID:3796
           
Identity:

                               
                                   0%
                               
                                   10%
                               
                                   20%
                               
                                   30%
                               
                                   40%
                               
                                   50%
                               
                                   60%
                               
                                   70%
                               
                                   80%
                               
                                   90%
                               
                                   100%
                               
                             

                           

     
HomologID
                           Accession
                           Description
                           Length
                           PctIdentity
                           PctSimilarity
                           Gaps
                           Score
     

     
     
6017
                           PA1757_tr
                           translation of PA1757
                           205
                           99.51
                           99.99
                           0
                           1045.0
     

     
     
167798
                           gb|AAG05146.1|AE004601_11
                           (AE004601) homoserine kinase [Pseudomonas aeruginosa PAO1]
                           205
                           99.02
                           99.99
                           0
                           1042.0
     

     
     
167799
                           emb|CAA07580.1|
                           (AJ007615) homoserine-kinase isozyme [Pseudomonas aeruginosa]
                           205
                           98.53
                           99.51
                           0
                           1035.0
     

     
     
167800
                           gb|AAO55795.1|
                           (AE016864) hydrolase, haloacid dehalogenase-like family [Pseudomonas syringae pv. tomato str. DC3000]
                           237
                           75.52
                           82.70
                           32
                           943.0
     

     






      

          
GC ORFID: 46798How Found: BLASTX

          
GC_TrimmedSeqID: 69Blast Result ID

          
Subject Sequence Name: t_PA1757Glimmer Score: 

          
Start: 1215866Stop: 1216483

          
Length: 618


          
Start Codon: GTGTruncated Start:

          
Stop Codon: TAGTruncated Stop: 

          
Homolog: t_PA1757 translation of PA1757Homolog Bit Score 407.0

          
Other Homologs:  psyr_15may02_Scaffold1_revised_gene1060 (ORF: BLASTX 369.0), t_PA1757 (ORF: GLIMMER)

          
GC ORF Sequence

           
GTGGAAATTGCCTGTCTTGACCTGGAAGGCGTGCTGGTTCCGGAAATCTGGATCGCGTTCGCGGAAAAAACC 
GGTATCGACGCCTTGAAGGCGACCACCCGGGACATTCCGGACTACGACGTGCTGATGAAGCAGCGCCTGCGC 
ATTCTCGACGAACATGGCCTGAAGCTGGGCGATATCCAGGAGGTGATCGCCACCCTGAAGCCGCTGGAGGGG 
GCGGTGGAATTCGTCGACTGGCTGCGCGAGCGCTTCCAGGTGGTGATCCTCTCCGACACCTTCTACGAGTTC 
TCCCAGCCGCTGATGCGCCAGCTGGGCTTCCCGACCCTGTTGTGCCACAAGCTGGAGATCGACGACAGCGAC 
CGGGTGGTCGGCTATCGATTGCGCCAGAAGGATCCCAAGCGGCAGTCGGTGATCGCCTTCAAGAGCCTCTAC 
TACCGGGTGATCGCCGCAGGCGACTCCTACAACGACACCACCATGCTTTCCGAGGCCCACGCCGGCATCCTG 
TTCCATGCCCCGGAAAACGTGATCCGCGAGTTTCCCCAGTTCCCCGCGGTGCATACCTACGAAGACCTCAAG 
CGCGAGTTCCTCAAGGCTTCCAGCCGTTCGCTGAGCCTGTAG