ViewGene
Locus Name:
GeneID:
Location:

GeneID:2912
TrivialName: PA14_52990
AnnotatorUID:
Modification Date/Time:2006-04-06 13:01:23
LocusName:PA14_52990
PAO1 Ortholog Locus:PA0872
Sequence Length:789
Protein Length:262
Start: 4698197
Stop: 4698985
Strand: +
Type:
ChromosomeID:2
Status: ACTIVE
Frame Discrepancy: FALSE
Missense Discrepancy:FALSE
Comments:
Homology: gb|AAG04261.1|AE004522_3 (AE004522) phenylalanine-4-hydroxylase [Pseudomonas aeruginosa PAO1]
Identities = 261/262 (99%), Positives = 261/262 (99%)
Sequence:
ATGAAAACGACGCAGTACGTGGCCCGCCAGCCCGACGACAACGGTTTCATCCACTATCCGGAAACCGAGCAC
CAGGTCTGGAATACCCTGATCACCCGGCAACTGAAGGTGATCGAAGGCCGCGCCTGTCAGGAATACCTCGAC
GGCATCGAACAGCTCGGCCTGCCCCACGAGCGGATCCCCCAGCTCGACGAGATCAACAGGGTTCTCCAGGCC
ACCACCGGCTGGCGCGTGGCGCGGGTTCCGGCGCTGATTCCGTTCCAGACCTTCTTCGAACTGCTGGCCAGC
CAGCAATTCCCCGTCGCCACCTTTATCCGCACCCCGGAAGAACTGGACTACCTGCAGGAGCCGGACATCTTC
CACGAGATCTTCGGCCACTGCCCACTGCTGACCAACCCCTGGTTCGCCGAGTTCACCCATACCTACGGCAAG
CTCGGCCTCAAGGCGAGCAAGGAGGAACGCGTGTTCCTCGCCCGCCTGTACTGGATGACCATCGAGTTCGGC
CTGGTCGAGACCGACCAGGGCAAGCGCATCTACGGCGGCGGCATCCTCTCCTCGCCGAAGGAGACCGTCTAC
TGCCTCTCCGACGAGCCGCTGCACCAGGCCTTCAATCCGCTGGAGGCGATGCGCACGCCCTACCGCATCGAC
ATCCTGCAACCGCTCTATTTCGTCCTGCCCGACCTCAAGCGCCTGTTCCAACTGGCCCAGGAAGACATCATG
GCACTGGTCCACGAGGCCATGCGCCTGGGCCTGCACGCGCCGCTGTTCCCGCCCAAGCAGGCGGCCTGA
Translation:
MKTTQYVARQPDDNGFIHYPETEHQVWNTLITRQLKVIEGRACQEYLDGIEQLGLPHERIPQLDEINRVLQA
TTGWRVARVPALIPFQTFFELLASQQFPVATFIRTPEELDYLQEPDIFHEIFGHCPLLTNPWFAEFTHTYGK
LGLKASKEERVFLARLYWMTIEFGLVETDQGKRIYGGGILSSPKETVYCLSDEPLHQAFNPLEAMRTPYRID
ILQPLYFVLPDLKRLFQLAQEDIMALVHEAMRLGLHAPLFPPKQAA*
AnnotationID:2920GeneID:2912
AnnotatorUID: danlee
Modification Date/Time: 2004-05-03 12:12:14
Gene Name:phhA
Confidence Code:1
GeneProduct:phenylalanine-4-hydroxylase
Cell Localization:()
Synonyms:PA0872
Cell Localization Confidence Code:5
MolecularFunction:
Functional Category:(2) Amino acid biosynthesis and metabolism
Alternate Gene Product Name:phenylalanine 4-monooxygenase 
Functional Category Confidence Code:5
COGs:COG3186
Secondary Functional Category(ies):
EC Number:
Status:ACTIVE
Pathway:
Phenylalanine, tyrosine and tryptophan biosynthesis 
Homology:






 
Structural Features:
COG3186, Phenylalanine-4-hydroxylase [Amino acid transport and metabolism]
        CD-Length = 291 residues,  91.4% aligned
        Score =  386 bits (993), Expect = 3e-108






   
Genomic Context:
The second gene of a 4-gene cluster encoding phenylalanine hydroxylase (PhhA),
carbinolamine dehydratase (PhhB), and aromatic aminotransferase (PhhC);
and in the upstream region, a divergently transcribed gene (phhR) encoding an activator protein.






   
Comment:


















    ReferenceID:5827




  
Author/Investigator(s):
        GenNotator





  
Title:
        




  
PubMed:
        


MedLine:
        




    
Source:






    
Reference Type:BLASTP 







    
Data:


    		




 
URL:

















    ReferenceID:22969




  
Author/Investigator(s):
        GenNotator





  
Title:
        CDD Search




  
PubMed:
        


MedLine:
        




    
Source:






    
Reference Type:RPSBLAST 







    
Data:


    		




 
URL:

















    ReferenceID:31992




  
Author/Investigator(s):
        Zhao G, Xia T, Song J, Jensen RA.






  
Title:
        Pseudomonas aeruginosa possesses homologues of mammalian phenylalanine hydroxylase and 4 alpha-carbinolamine dehydratase/DCoH as part of a three-component gene cluster.





  
PubMed:
        94151331


MedLine:
        




    
Source:
Proc Natl Acad Sci U S A. 1994 Feb 15;91(4):1366-70.






    
Reference Type:Journal 







    
Data:


    		




 
URL:









           
Homologs By Global Alignment 

           

       



     
Gene ID:2912
           
Identity:

                               
                                   0%
                               
                                   10%
                               
                                   20%
                               
                                   30%
                               
                                   40%
                               
                                   50%
                               
                                   60%
                               
                                   70%
                               
                                   80%
                               
                                   90%
                               
                                   100%
                               
                             

                           

     
HomologID
                           Accession
                           Description
                           Length
                           PctIdentity
                           PctSimilarity
                           Gaps
                           Score
     

     
     
4713
                           PA0872_tr
                           translation of PA0872
                           262
                           99.61
                           99.61
                           0
                           1385.0
     

     
     
135523
                           gb|AAG04261.1|AE004522_3
                           (AE004522) phenylalanine-4-hydroxylase [Pseudomonas aeruginosa PAO1]
                           262
                           99.61
                           99.61
                           0
                           1385.0
     

     
     
135524
                           gb|AAA25936.1|
                           (M88627) phenylalanine hydroxylase [Pseudomonas aeruginosa]
                           262
                           99.23
                           99.23
                           0
                           1379.0
     

     
     
135525
                           gb|AAN70065.1|AE016646_2
                           (AE016790) phenylalanine-4-hydroxylase [Pseudomonas putida KT2440]
                           262
                           84.73
                           93.51
                           0
                           1203.0
     

     
     
135526
                           gb|AAO55341.1|
                           (AE016862) phenylalanine-4-hydroxylase [Pseudomonas syringae pv. tomato str. DC3000]
                           265
                           78.86
                           87.54
                           3
                           1135.0
     

     






      

          
GC ORFID: 45914How Found: BLASTX

          
GC_TrimmedSeqID: 69Blast Result ID

          
Subject Sequence Name: t_PA0872Glimmer Score: 

          
Start: 255710Stop: 254922

          
Length: 789


          
Start Codon: ATGTruncated Start:

          
Stop Codon: TGATruncated Stop: 

          
Homolog: t_PA0872 translation of PA0872Homolog Bit Score 538.0

          
Other Homologs:  psyr_15may02_Scaffold8_revised_gene7623 (ORF: BLASTX 434.0), t_PA0872 (ORF: GLIMMER)

          
GC ORF Sequence

           
ATGAAAACGACGCAGTACGTGGCCCGCCAGCCCGACGACAACGGTTTCATCCACTATCCGGAAACCGAGCAC 
CAGGTCTGGAATACCCTGATCACCCGGCAACTGAAGGTGATCGAAGGCCGCGCCTGTCAGGAATACCTCGAC 
GGCATCGAACAGCTCGGCCTGCCCCACGAGCGGATCCCCCAGCTCGACGAGATCAACAGGGTTCTCCAGGCC 
ACCACCGGCTGGCGCGTGGCGCGGGTTCCGGCGCTGATTCCGTTCCAGACCTTCTTCGAACTGCTGGCCAGC 
CAGCAATTCCCCGTCGCCACCTTTATCCGCACCCCGGAAGAACTGGACTACCTGCAGGAGCCGGACATCTTC 
CACGAGATCTTCGGCCACTGCCCACTGCTGACCAACCCCTGGTTCGCCGAGTTCACCCATACCTACGGCAAG 
CTCGGCCTCAAGGCGAGCAAGGAGGAACGCGTGTTCCTCGCCCGCCTGTACTGGATGACCATCGAGTTCGGC 
CTGGTCGAGACCGACCAGGGCAAGCGCATCTACGGCGGCGGCATCCTCTCCTCGCCGAAGGAGACCGTCTAC 
TGCCTCTCCGACGAGCCGCTGCACCAGGCCTTCAATCCGCTGGAGGCGATGCGCACGCCCTACCGCATCGAC 
ATCCTGCAACCGCTCTATTTCGTCCTGCCCGACCTCAAGCGCCTGTTCCAACTGGCCCAGGAAGACATCATG 
GCACTGGTCCACGAGGCCATGCGCCTGGGCCTGCACGCGCCGCTGTTCCCGCCCAAGCAGGCGGCCTGA