ViewGene
Locus Name:
GeneID:
Location:

GeneID:2025
TrivialName: PA14_47720
AnnotatorUID:
Modification Date/Time:2006-04-06 13:01:23
LocusName:PA14_47720
PAO1 Ortholog Locus:PA1276
Sequence Length:996
Protein Length:331
Start: 4247342
Stop: 4246347
Strand: -
Type:
ChromosomeID:2
Status: ACTIVE
Frame Discrepancy: FALSE
Missense Discrepancy:FALSE
Comments:
Homology: gb|AAG04665.1|AE004557_6 (AE004557) cobalamin biosynthetic protein CobC [Pseudomonas aeruginosa PAO1]
Identities = 329/331 (99%), Positives = 330/331 (99%)
Sequence:
ATGCTTGAACACGGAGGGCGGTTGCGCGAGGCGGCGCGCCGCTACGACATTCCGCTGGCGGACTGGCTGGAC
CTGTCCACCGGCATCGCGCCCTGGCCGTTTCCGCTGCCGGCGATCCCCGAGCAGGCCTGGACCCGCCTGCCG
GAGAGCGACGACGGCCTGGAAGCCGCCGCCTGCCTCTACTACGGCGCCGAACGGGTATTGCCGCTGGCCGGC
AGCCAGGCGGCGATCCAGGCCCTGCCAAGGTTGCGGCGGGGCGGGCGGGTCGGCGTCCTGTCGCCGTGCTAC
GCCGAGCACGCCCACGCCTGGCGCCAGGCCGGGCACCTGGTGCGGGAGATCGGCGAGGCCGAGGTCGAGCCC
TATCTCGACAGCCTCGACGTGCTGCTGGTGGTCAACCCGAACAACCCCACCGGGCGGGTCTTCGAGCCCGCC
GAGCTGCTGGCCTGGCATGCCCGCCTGCAACGTCGCGGCGGCTGGCTGCTGGTCGACGAGGCGTTCATGGAC
TGCACCCCGCAGTCGAGCCTGGCGGCCTGCAGCAACCGGCCCGGATTGATCGTGCTGCGCTCGTTCGGCAAG
TTCTTCGGCCTGGCCGGCGCGCGGCTCGGCTTCGCCCTCGGCGAACGGCCGCTGTTGCAGGCGCTGGCCGAG
CAGCTCGGTCCGTGGACGGTCAATGGCCCGGTGCGCCATGTGGCCCAGAGCGCCTTGCGCGACCGCCAGCAA
CAGCGCCAGCAGCGCGAGCGCCTGCTGGCCGCCAGCCAGCGCCTGGAGGAACTGCTGCGCCGCCACGGCTGG
CCGCCGGCGGGCGGCAGCGCGCTGTTCCAGCGCCTGGTCGATCCACGCTGCGCGGCGTTGCACGACTACCTG
GCACGGCGCGGCATCCTCACCCGCCAGTTCGAGCAGCCGGCCAGCCTGCGCCTCGGCCTGCCCGCCGACGAG
GCCGCCTGGGCCCGGCTCGATGCCGCGCTGCTCGGCTTCAAGGAGCCTGCTCATGAGTGA
Translation:
MLEHGGRLREAARRYDIPLADWLDLSTGIAPWPFPLPAIPEQAWTRLPESDDGLEAAACLYYGAERVLPLAG
SQAAIQALPRLRRGGRVGVLSPCYAEHAHAWRQAGHLVREIGEAEVEPYLDSLDVLLVVNPNNPTGRVFEPA
ELLAWHARLQRRGGWLLVDEAFMDCTPQSSLAACSNRPGLIVLRSFGKFFGLAGARLGFALGERPLLQALAE
QLGPWTVNGPVRHVAQSALRDRQQQRQQRERLLAASQRLEELLRRHGWPPAGGSALFQRLVDPRCAALHDYL
ARRGILTRQFEQPASLRLGLPADEAAWARLDAALLGFKEPAHE*
AnnotationID:2034GeneID:2025
AnnotatorUID: diggins
Modification Date/Time: 2005-04-27 07:07:59
Gene Name:cobC
Confidence Code:2
GeneProduct:cobalamin biosynthesis protein CobC
Cell Localization:()
Synonyms:
Cell Localization Confidence Code:5
MolecularFunction:
Functional Category:(4) Biosynthesis of cofactors, prosthetic groups and carriers
Alternate Gene Product Name:
Functional Category Confidence Code:5
COGs:COG0079
Secondary Functional Category(ies):
EC Number:4.1.1.81, 3.1.3.73
Status:ACTIVE
Pathway:






 
Homology:
>gb|AAN67297.1|AE016356_5 (AE016780) cobalamin biosynthesis protein CobC [Pseudomonas putida
           KT2440]
          Length = 330

 Score =  408 bits (1049), Expect = e-113
 Identities = 206/327 (62%), Positives = 241/327 (73%)

>gb|AAM38033.1| (AE011964) cobalamin biosynthetic protein [Xanthomonas axonopodis
           pv. citri str. 306]
          Length = 327

 Score =  367 bits (941), Expect = e-101
 Identities = 189/322 (58%), Positives = 226/322 (70%)

>gb|AAM42332.1| (AE012420) cobyric acid synthase [Xanthomonas campestris pv.
           campestris str. ATCC 33913]
          Length = 818

 Score =  346 bits (888), Expect = 1e-94
 Identities = 185/313 (59%), Positives = 215/313 (68%), Gaps = 6/313 (1%)








 
Structural Features:
COG0079, HisC, Histidinol-phosphate/aromatic aminotransferase 
and cobyric acid decarboxylase 
[Amino acid transport and metabolism]
CD-Length = 356 residues,  98.0% aligned
Score =  214 bits (546), Expect = 1e-56
Identities = 107/353 (30%), Positives = 161/353 (45%), Gaps = 30/353 (8%)






   
Genomic Context:






   
Comment:


















    ReferenceID:4053




  
Author/Investigator(s):
        GenNotator





  
Title:
        




  
PubMed:
        


MedLine:
        




    
Source:






    
Reference Type:BLASTP 







    
Data:


    		




 
URL:

















    ReferenceID:21199




  
Author/Investigator(s):
        GenNotator





  
Title:
        CDD Search




  
PubMed:
        


MedLine:
        




    
Source:






    
Reference Type:RPSBLAST 







    
Data:


    		




 
URL:

















    ReferenceID:37512




  
Author/Investigator(s):
        





  
Title:
        CDD Search




  
PubMed:
        


MedLine:
        




    
Source:






    
Reference Type:Misc (text/plain)







    
Data:2025_cdd.html


    		




 
URL:

















    ReferenceID:38027




  
Author/Investigator(s):
        Crouzet J, Cauchois L, Blanche F, Debussche L, Thibaut D, Rouyez MC, Rigault S, Mayaux JF, Cameron B.





  
Title:
        Nucleotide sequence of a Pseudomonas denitrificans 5.4-kilobase DNA fragment containing five cob genes and identification of structural genes encoding S-adenosyl-L-methionine: uroporphyrinogen III methyltransferase and cobyrinic acid a,c-diamide synthase.




  
PubMed:
        2211520


MedLine:
        




    
Source:
J Bacteriol. 1990 Oct;172(10):5968-79.






    
Reference Type:Journal 







    
Data:


    		




 
URL:http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=2211520

















    ReferenceID:38030




  
Author/Investigator(s):
        O'Toole GA, Trzebiatowski JR, Escalante-Semerena JC.





  
Title:
        The cobC gene of Salmonella typhimurium codes for a novel phosphatase involved in the assembly of the nucleotide loop of cobalamin.




  
PubMed:
        7929373


MedLine:
        




    
Source:
J Biol Chem. 1994 Oct 21;269(42):26503-11.






    
Reference Type:Journal 







    
Data:


    		




 
URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=7929373









           
Homologs By Global Alignment 

           

       



     
Gene ID:2025
           
Identity:

                               
                                   0%
                               
                                   10%
                               
                                   20%
                               
                                   30%
                               
                                   40%
                               
                                   50%
                               
                                   60%
                               
                                   70%
                               
                                   80%
                               
                                   90%
                               
                                   100%
                               
                             

                           

     
HomologID
                           Accession
                           Description
                           Length
                           PctIdentity
                           PctSimilarity
                           Gaps
                           Score
     

     
     
3515
                           PA1276_tr
                           translation of PA1276
                           331
                           99.39
                           99.69
                           0
                           1732.0
     

     
     
107589
                           gb|AAG04665.1|AE004557_6
                           (AE004557) cobalamin biosynthetic protein CobC [Pseudomonas aeruginosa PAO1]
                           331
                           99.39
                           99.69
                           0
                           1732.0
     

     
     
107590
                           gb|AAO55232.1|
                           (AE016861) cobalamin biosynthesis protein CobC [Pseudomonas syringae pv. tomato str. DC3000]
                           336
                           63.39
                           74.40
                           7
                           1065.0
     

     
     
107591
                           gb|AAN67297.1|AE016356_5
                           (AE016780) cobalamin biosynthesis protein CobC [Pseudomonas putida KT2440]
                           332
                           62.95
                           72.89
                           3
                           1050.0
     

     
     
107592
                           gb|AAM38033.1|
                           (AE011964) cobalamin biosynthetic protein [Xanthomonas axonopodis pv. citri str. 306]
                           334
                           56.88
                           67.96
                           10
                           934.0
     

     






      

          
GC ORFID: 45027How Found: BLASTX

          
GC_TrimmedSeqID: 69Blast Result ID

          
Subject Sequence Name: t_PA1276Glimmer Score: 

          
Start: 706567Stop: 707562

          
Length: 996


          
Start Codon: ATGTruncated Start:

          
Stop Codon: TGATruncated Stop: 

          
Homolog: t_PA1276 translation of PA1276Homolog Bit Score 671.0

          
Other Homologs:  t_PA1276 (ORF: GLIMMER)

          
GC ORF Sequence

           
ATGCTTGAACACGGAGGGCGGTTGCGCGAGGCGGCGCGCCGCTACGACATTCCGCTGGCGGACTGGCTGGAC 
CTGTCCACCGGCATCGCGCCCTGGCCGTTTCCGCTGCCGGCGATCCCCGAGCAGGCCTGGACCCGCCTGCCG 
GAGAGCGACGACGGCCTGGAAGCCGCCGCCTGCCTCTACTACGGCGCCGAACGGGTATTGCCGCTGGCCGGC 
AGCCAGGCGGCGATCCAGGCCCTGCCAAGGTTGCGGCGGGGCGGGCGGGTCGGCGTCCTGTCGCCGTGCTAC 
GCCGAGCACGCCCACGCCTGGCGCCAGGCCGGGCACCTGGTGCGGGAGATCGGCGAGGCCGAGGTCGAGCCC 
TATCTCGACAGCCTCGACGTGCTGCTGGTGGTCAACCCGAACAACCCCACCGGGCGGGTCTTCGAGCCCGCC 
GAGCTGCTGGCCTGGCATGCCCGCCTGCAACGTCGCGGCGGCTGGCTGCTGGTCGACGAGGCGTTCATGGAC 
TGCACCCCGCAGTCGAGCCTGGCGGCCTGCAGCAACCGGCCCGGATTGATCGTGCTGCGCTCGTTCGGCAAG 
TTCTTCGGCCTGGCCGGCGCGCGGCTCGGCTTCGCCCTCGGCGAACGGCCGCTGTTGCAGGCGCTGGCCGAG 
CAGCTCGGTCCGTGGACGGTCAATGGCCCGGTGCGCCATGTGGCCCAGAGCGCCTTGCGCGACCGCCAGCAA 
CAGCGCCAGCAGCGCGAGCGCCTGCTGGCCGCCAGCCAGCGCCTGGAGGAACTGCTGCGCCGCCACGGCTGG 
CCGCCGGCGGGCGGCAGCGCGCTGTTCCAGCGCCTGGTCGATCCACGCTGCGCGGCGTTGCACGACTACCTG 
GCACGGCGCGGCATCCTCACCCGCCAGTTCGAGCAGCCGGCCAGCCTGCGCCTCGGCCTGCCCGCCGACGAG 
GCCGCCTGGGCCCGGCTCGATGCCGCGCTGCTCGGCTTCAAGGAGCCTGCTCATGAGTGA