ViewGene
Locus Name:
GeneID:
Location:

GeneID:1908
TrivialName: PA14_57770
AnnotatorUID:
Modification Date/Time:2006-04-06 13:01:23
LocusName:PA14_57770
PAO1 Ortholog Locus:PA4447
Sequence Length:1056
Protein Length:351
Start: 5145692
Stop: 5144637
Strand: -
Type:
ChromosomeID:2
Status: ACTIVE
Frame Discrepancy: FALSE
Missense Discrepancy:FALSE
Comments:
Homology: gb|AAG07835.1|AE004859_4 (AE004859) histidinol-phosphate aminotransferase [Pseudomonas aeruginosa PAO1]
Identities = 349/351 (99%), Positives = 350/351 (99%)
Sequence:
ATGAGCAAATTCTGGAGTCCCTTCGTCAAGGACCTGGTGCCTTATGTGCCGGGCGAGCAGCCGAAGCTGTCG
CGGCTGGTCAAGCTGAACACCAACGAGAATCCCTACGGTCCGTCGCCACAGGCGCTCGCCGCGATGCAGGCG
GAACTCAACGACGACCTGCGCCTGTATCCCGATCCCAACGGCGAGCGGTTGAAGCAGGCGGTCGCCGCGCAC
TACGGCGTACAGGCCAACCAGGTGTTCGTCGGCAACGGCTCCGACGAGGTGCTCGCGCACATTTTCCATGGC
CTGTTCCAACACGACCTGCCGCTTCTGTTCCCGGACGTGACCTACAGCTTCTACCCGGTCTATTGCGGCCTG
TACGGGGTCGCGCACGAGAAGATCACGTTGGATGAAAGGTTCCGCATCCGCGTCGAAGACTACGCGCGGCCC
AACGGCGGAATCATCTTCCCCAATCCGAACGCGCCGACCGGCTGCCTGCTGCCGCTGGACGCCATCGAAGCG
ATGCTGAAGGCGTCGCCGGATTCGGTGGTGGTGGTCGACGAGGCCTATGTCGACTTCGGTGGCGAGAGCGCC
ATCGCCCTGGTCGATCGCTACCCGAACCTGCTGGTCACCCAGACGCTGTCCAAGTCGCGCTCCCTGGCCGGC
CTGCGGGTCGGCCTGGCGGTCGGCCATGCCGATCTGGTCGAGGCGCTGGAGCGGATCAAGAACAGCTTCAAT
TCCTACCCGCTGGATCGCCTGGCGATCGCCGGCGCGGCGGCGGCTTTCGAGGACGACGCCTATTTCCGTCGG
ACCTGCCAGGCAGTGATCGATAGCCGCGAGGCGTTGAGCGCCTCTTTGCAGGCGCTGGGCTTCGAGGTACTA
CCGTCGGCCGCCAACTTCGTCTTCGCCCGTCATCCGCGGCACGATGCCGGGCAGATTGCCTCGACCCTGCGC
GAGCAGGGAGTGATCGTCCGCCATTTCAAGCAGGCGCGGATCGACCAGTTCCTGCGTATCACCATCGGCAGT
CCGGAGCAGAACCAGGCGCTACTGGACGCCCTGCACTTCCTCAAGTGA
Translation:
MSKFWSPFVKDLVPYVPGEQPKLSRLVKLNTNENPYGPSPQALAAMQAELNDDLRLYPDPNGERLKQAVAAH
YGVQANQVFVGNGSDEVLAHIFHGLFQHDLPLLFPDVTYSFYPVYCGLYGVAHEKITLDERFRIRVEDYARP
NGGIIFPNPNAPTGCLLPLDAIEAMLKASPDSVVVVDEAYVDFGGESAIALVDRYPNLLVTQTLSKSRSLAG
LRVGLAVGHADLVEALERIKNSFNSYPLDRLAIAGAAAAFEDDAYFRRTCQAVIDSREALSASLQALGFEVL
PSAANFVFARHPRHDAGQIASTLREQGVIVRHFKQARIDQFLRITIGSPEQNQALLDALHFLK*
AnnotationID:1917GeneID:1908
AnnotatorUID: diggins
Modification Date/Time: 2005-05-03 05:05:38
Gene Name:hisC1
Confidence Code:2
GeneProduct: histidinol-phosphate aminotransferase
Cell Localization:()
Synonyms:his8
Cell Localization Confidence Code:5
MolecularFunction:
Functional Category:(2) Amino acid biosynthesis and metabolism
Alternate Gene Product Name: imidazole acetol-phosphate transaminase
Functional Category Confidence Code:5
COGs:COG0079,KOG0633
Secondary Functional Category(ies):
EC Number:2.6.1.9
Status:ACTIVE
Pathway:






 
Homology:
>gb|AAN66592.1|AE016287_3 (AE016777) histidinol-phosphate aminotransferase [Pseudomonas
           putida KT2440]
          Length = 348

 Score =  582 bits (1500), Expect = e-165
 Identities = 281/347 (80%), Positives = 313/347 (90%)

>gb|AAO57886.1| (AE016872) histidinol-phosphate aminotransferase [Pseudomonas
           syringae pv. tomato str. DC3000]
          Length = 350

 Score =  558 bits (1437), Expect = e-158
 Identities = 270/347 (77%), Positives = 304/347 (87%)






 
Structural Features:
COG0079, HisC, Histidinol-phosphate/aromatic aminotransferase and c
obyric acid decarboxylase 
[Amino acid transport and metabolism]
CD-Length = 356 residues,  97.8% aligned
Score =  310 bits (796), Expect = 3e-85
Identities = 142/353 (40%), Positives = 208/353 (58%), Gaps = 14/353 (3%)

KOG0633, Histidinol phosphate aminotransferase 
[Amino acid transport and metabolism]
CD-Length = 375 residues,  87.7% aligned
Score =  154 bits (390), Expect = 3e-38
Identities = 111/340 (32%), Positives = 160/340 (47%), Gaps = 29/340 (8%)






   
Genomic Context:






   
Comment:


















    ReferenceID:3819




  
Author/Investigator(s):
        GenNotator





  
Title:
        




  
PubMed:
        


MedLine:
        




    
Source:






    
Reference Type:BLASTP 







    
Data:


    		




 
URL:

















    ReferenceID:20966




  
Author/Investigator(s):
        GenNotator





  
Title:
        CDD Search




  
PubMed:
        


MedLine:
        




    
Source:






    
Reference Type:RPSBLAST 







    
Data:


    		




 
URL:

















    ReferenceID:31485




  
Author/Investigator(s):
        





  
Title:
        CDD Search




  
PubMed:
        


MedLine:
        




    
Source:






    
Reference Type:Misc (text/plain)







    
Data:1908_cdd.html


    		




 
URL:

















    ReferenceID:32841




  
Author/Investigator(s):
        Sivaraman J, Li Y, Larocque R, Schrag JD, Cygler M, Matte A.





  
Title:
        Crystal structure of histidinol phosphate aminotransferase (HisC) from Escherichia coli, and its covalent complex with pyridoxal-5'-phosphate and l-histidinol phosphate.




  
PubMed:
        11518529


MedLine:
        




    
Source:
J Mol Biol. 2001 Aug 24;311(4):761-76.






    
Reference Type:Journal 







    
Data:


    		




 
URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11518529

















    ReferenceID:32842




  
Author/Investigator(s):
        Grisolia V, Carlomagno MS, Nappo AG, Bruni CB.





  
Title:
        Cloning, structure, and expression of the Escherichia coli K-12 hisC gene.




  
PubMed:
        2999081


MedLine:
        




    
Source:
J Bacteriol. 1985 Dec;164(3):1317-23.






    
Reference Type:Journal 







    
Data:


    		




 
URL:http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=2999081

















    ReferenceID:32843




  
Author/Investigator(s):
        Riggs D, Artz S.





  
Title:
        The hisD-hisC gene border of the Salmonella typhimurium histidine operon.




  
PubMed:
        6390096


MedLine:
        




    
Source:
Mol Gen Genet. 1984;196(3):526-9.






    
Reference Type:Journal 







    
Data:


    		




 
URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=6390096









           
Homologs By Global Alignment 

           

       



     
Gene ID:1908
           
Identity:

                               
                                   0%
                               
                                   10%
                               
                                   20%
                               
                                   30%
                               
                                   40%
                               
                                   50%
                               
                                   60%
                               
                                   70%
                               
                                   80%
                               
                                   90%
                               
                                   100%
                               
                             

                           

     
HomologID
                           Accession
                           Description
                           Length
                           PctIdentity
                           PctSimilarity
                           Gaps
                           Score
     

     
     
3361
                           PA4447_tr
                           translation of PA4447
                           351
                           99.43
                           99.71
                           0
                           1802.0
     

     
     
104212
                           gb|AAG07835.1|AE004859_4
                           (AE004859) histidinol-phosphate aminotransferase [Pseudomonas aeruginosa PAO1]
                           351
                           99.43
                           99.71
                           0
                           1802.0
     

     
     
104213
                           gb|AAN66592.1|AE016287_3
                           (AE016777) histidinol-phosphate aminotransferase [Pseudomonas putida KT2440]
                           351
                           80.05
                           89.17
                           3
                           1499.0
     

     
     
104214
                           gb|AAO57886.1|
                           (AE016872) histidinol-phosphate aminotransferase [Pseudomonas syringae pv. tomato str. DC3000]
                           351
                           76.92
                           86.89
                           1
                           1435.0
     

     
     
104215
                           emb|CAE38142.1|
                           (BX640431) histidinol-phosphate aminotransferase [Bordetella parapertussis]
                           356
                           64.60
                           78.08
                           5
                           1184.0
     

     






      

          
GC ORFID: 44910How Found: BLASTX

          
GC_TrimmedSeqID: 69Blast Result ID

          
Subject Sequence Name: t_PA4447Glimmer Score: 

          
Start: 4409371Stop: 4408316

          
Length: 1056


          
Start Codon: ATGTruncated Start:

          
Stop Codon: TGATruncated Stop: 

          
Homolog: t_PA4447 translation of PA4447Homolog Bit Score 698.0

          
Other Homologs:  psyr_15may02_Scaffold4_revised_gene5528 (ORF: BLASTX 555.0), t_PA4447 (ORF: GLIMMER)

          
GC ORF Sequence

           
ATGAGCAAATTCTGGAGTCCCTTCGTCAAGGACCTGGTGCCTTATGTGCCGGGCGAGCAGCCGAAGCTGTCG 
CGGCTGGTCAAGCTGAACACCAACGAGAATCCCTACGGTCCGTCGCCACAGGCGCTCGCCGCGATGCAGGCG 
GAACTCAACGACGACCTGCGCCTGTATCCCGATCCCAACGGCGAGCGGTTGAAGCAGGCGGTCGCCGCGCAC 
TACGGCGTACAGGCCAACCAGGTGTTCGTCGGCAACGGCTCCGACGAGGTGCTCGCGCACATTTTCCATGGC 
CTGTTCCAACACGACCTGCCGCTTCTGTTCCCGGACGTGACCTACAGCTTCTACCCGGTCTATTGCGGCCTG 
TACGGGGTCGCGCACGAGAAGATCACGTTGGATGAAAGGTTCCGCATCCGCGTCGAAGACTACGCGCGGCCC 
AACGGCGGAATCATCTTCCCCAATCCGAACGCGCCGACCGGCTGCCTGCTGCCGCTGGACGCCATCGAAGCG 
ATGCTGAAGGCGTCGCCGGATTCGGTGGTGGTGGTCGACGAGGCCTATGTCGACTTCGGTGGCGAGAGCGCC 
ATCGCCCTGGTCGATCGCTACCCGAACCTGCTGGTCACCCAGACGCTGTCCAAGTCGCGCTCCCTGGCCGGC 
CTGCGGGTCGGCCTGGCGGTCGGCCATGCCGATCTGGTCGAGGCGCTGGAGCGGATCAAGAACAGCTTCAAT 
TCCTACCCGCTGGATCGCCTGGCGATCGCCGGCGCGGCGGCGGCTTTCGAGGACGACGCCTATTTCCGTCGG 
ACCTGCCAGGCAGTGATCGATAGCCGCGAGGCGTTGAGCGCCTCTTTGCAGGCGCTGGGCTTCGAGGTACTA 
CCGTCGGCCGCCAACTTCGTCTTCGCCCGTCATCCGCGGCACGATGCCGGGCAGATTGCCTCGACCCTGCGC 
GAGCAGGGAGTGATCGTCCGCCATTTCAAGCAGGCGCGGATCGACCAGTTCCTGCGTATCACCATCGGCAGT 
CCGGAGCAGAACCAGGCGCTACTGGACGCCCTGCACTTCCTCAAGTGA