ViewGene
Locus Name:
GeneID:
Location:

GeneID:1636
TrivialName: PA14_33860
AnnotatorUID:
Modification Date/Time:2006-04-06 13:01:23
LocusName:PA14_33860
PAO1 Ortholog Locus:PA2382
Sequence Length:1152
Protein Length:383
Start: 3008839
Stop: 3009990
Strand: +
Type:
ChromosomeID:2
Status: ACTIVE
Frame Discrepancy: FALSE
Missense Discrepancy:FALSE
Comments:
Homology: gb|AAG05770.1|AE004664_7 (AE004664) L-lactate dehydrogenase [Pseudomonas aeruginosa PAO1]
Identities = 383/383 (100%), Positives = 383/383 (100%)
Sequence:
ATGAGCGTCATCACCGATATCGAAGACCTGCGCCGCCTGGCGCGCAAGCGCGTGCCGCGGATGTTCTACGAC
TACGCCGACTCCGGTTCCTGGAGCGAAGGCACCTACCGCGCCAACCAGGACGACTTCGCCGCGATCAAGCTG
CGCCAGCGGGTCGCGCGGAATATCGAGAACCGCTCGCTGCGCACCCGCATGCTCGGCCAGGAGATGGCCATG
CCGGTGGCCATCGCGCCCACCGGGCTGGCCGGCATGCAGCATGCCGACGGCGAGATCCTCGCCGCCCGCGCC
GCCGCCGAGTTCGGCGTGCGCTACACCCTGTCGACCATGAGCATCTGTTCCCTGGAGGACATCGCCACGGAA
GTCGGCCAGCCGTTCTGGTTCCAGCTCTACGTGATGCGCGACCGCGATTTCATCGAACGCCTGATCGACCGT
GCCAAGGCCGCCGGCTGCGACGCGCTGGTGCTGACCCTCGACCTGCAGATCATCGGCCAGCGCCACAAGGAC
CTGAAGAACGGCCTCTCGGCGCCGCCGCGGCCGACCCTGGCCAACCTGCTGAACATCGCCACCAAGCCGCGC
TGGGCGCTGGGCATGCTCGGCACCCGGCGTCGCGGTTTCGGCAACATAGTCGGGCACGTCAAGGGCGTCGAC
GACATGGGCTCGCTGTCCGAGTGGACCGCCCGCCAGTTCGACCCGCGGCTGAACTGGGGCGACGTCGAATGG
ATCAAGCGCCGCTGGGGCGGCAAGCTGGTGCTCAAGGGCATCCTCGATGCCGAGGATGCGCGGCTGGCCGCC
GACTCCGGCGCCGATGCGCTGGTCGTCAGCAACCATGGCGGACGCCAGCTGGATGGCGCGCCCTCGACCATC
AGCGCGCTGCCGGCGATCGTCGAGGCGGTGGGCGAGCGCATCGAGGTCTGGCTCGACAGCGGCATCCGTTCC
GGGCAGGACGTGCTCAAGGCCATCGCCCTCGGTGCGCGCGGGACCATGATCGGCCGTCCCTATCTCTACGGG
CTGGGCGCGCTGGGTCAGGCCGGGGTGACGCGGGCGCTGGAGATCATCGCTCGTGAGCTGGACCTGACCATG
GCCTTCTGCGGCCATACCGACATCCGCGAGGTCGGCCGGGACATCCTGTTGCCGGGAAGCTACCCGCGATAG
Translation:
MSVITDIEDLRRLARKRVPRMFYDYADSGSWSEGTYRANQDDFAAIKLRQRVARNIENRSLRTRMLGQEMAM
PVAIAPTGLAGMQHADGEILAARAAAEFGVRYTLSTMSICSLEDIATEVGQPFWFQLYVMRDRDFIERLIDR
AKAAGCDALVLTLDLQIIGQRHKDLKNGLSAPPRPTLANLLNIATKPRWALGMLGTRRRGFGNIVGHVKGVD
DMGSLSEWTARQFDPRLNWGDVEWIKRRWGGKLVLKGILDAEDARLAADSGADALVVSNHGGRQLDGAPSTI
SALPAIVEAVGERIEVWLDSGIRSGQDVLKAIALGARGTMIGRPYLYGLGALGQAGVTRALEIIARELDLTM
AFCGHTDIREVGRDILLPGSYPR*
AnnotationID:1645GeneID:1636
AnnotatorUID: diggins
Modification Date/Time: 2005-04-29 07:07:55
Gene Name:lldA
Confidence Code:2
GeneProduct:L-lactate dehydrogenase
Cell Localization:()
Synonyms:
Cell Localization Confidence Code:5
MolecularFunction:
Functional Category:(12) Energy metabolism
Alternate Gene Product Name:
Functional Category Confidence Code:5
COGs:pfam01070,COG1304
Secondary Functional Category(ies):putative enzyme
EC Number:1.1.2.3
Status:ACTIVE
Pathway:






 
Homology:
>emb|CAE44813.1| (BX640412) L-lactate dehydrogenase [Bordetella pertussis]
          Length = 387

 Score =  615 bits (1587), Expect = e-175
 Identities = 299/383 (78%), Positives = 337/383 (87%)

>gb|AAN34092.1|AE014585_7 (AE014585) L-lactate dehydrogenase [Brucella suis 1330]
          Length = 381

 Score =  546 bits (1406), Expect = e-154
 Identities = 263/376 (69%), Positives = 317/376 (84%)

>emb|CAB84819.1| (AL162756) L-lactate dehydrogenase [Neisseria meningitidis Z2491]
          Length = 390

 Score =  527 bits (1357), Expect = e-149
 Identities = 255/376 (67%), Positives = 304/376 (80%)








 
Structural Features:
pfam01070, FMN_dh, FMN-dependent dehydrogenase.
CD-Length = 353 residues, 100.0% aligned
Score =  425 bits (1094), Expect = 5e-120
Identities = 178/366 (48%), Positives = 234/366 (63%), Gaps = 14/366 (3%)

COG1304, LldD, L-lactate dehydrogenase (FMN-dependent) 
and related alpha-hydroxy acid dehydrogenases 
[Energy production and conversion]
CD-Length = 360 residues,  98.6% aligned
Score =  384 bits (988), Expect = 8e-108
Identities = 162/377 (42%), Positives = 218/377 (57%), Gaps = 22/377 (5%)






   
Genomic Context:






   
Comment:


















    ReferenceID:3275




  
Author/Investigator(s):
        GenNotator





  
Title:
        




  
PubMed:
        


MedLine:
        




    
Source:






    
Reference Type:BLASTP 







    
Data:


    		




 
URL:

















    ReferenceID:20422




  
Author/Investigator(s):
        GenNotator





  
Title:
        CDD Search




  
PubMed:
        


MedLine:
        




    
Source:






    
Reference Type:RPSBLAST 







    
Data:


    		




 
URL:

















    ReferenceID:32923




  
Author/Investigator(s):
        





  
Title:
        CDD




  
PubMed:
        


MedLine:
        




    
Source:






    
Reference Type:Misc (text/plain)







    
Data:1636_cdd.html


    		




 
URL:

















    ReferenceID:34482




  
Author/Investigator(s):
        Erwin AL, Gotschlich EC.





  
Title:
        Cloning of a Neisseria meningitidis gene for L-lactate dehydrogenase (L-LDH): evidence for a second meningococcal L-LDH with different regulation.




  
PubMed:
        8759842


MedLine:
        




    
Source:
J Bacteriol. 1996 Aug;178(16):4807-13.






    
Reference Type:Journal 







    
Data:


    		




 
URL:http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=8759842









           
Homologs By Global Alignment 

           

       



     
Gene ID:1636
           
Identity:

                               
                                   0%
                               
                                   10%
                               
                                   20%
                               
                                   30%
                               
                                   40%
                               
                                   50%
                               
                                   60%
                               
                                   70%
                               
                                   80%
                               
                                   90%
                               
                                   100%
                               
                             

                           

     
HomologID
                           Accession
                           Description
                           Length
                           PctIdentity
                           PctSimilarity
                           Gaps
                           Score
     

     
     
2894
                           PA2382_tr
                           translation of PA2382
                           383
                           99.99
                           99.99
                           0
                           1968.0
     

     
     
90368
                           gb|AAG05770.1|AE004664_7
                           (AE004664) L-lactate dehydrogenase [Pseudomonas aeruginosa PAO1]
                           383
                           99.99
                           99.99
                           0
                           1968.0
     

     
     
90369
                           emb|CAE44813.1|
                           (BX640412) L-lactate dehydrogenase [Bordetella pertussis] [Bordetella pertussis Tohama I]
                           387
                           77.26
                           87.08
                           4
                           1587.0
     

     
     
90370
                           emb|CAE39673.1|
                           (BX640436) L-lactate dehydrogenase [Bordetella parapertussis]
                           387
                           77.00
                           87.33
                           4
                           1584.0
     

     
     
90371
                           emb|CAE35344.1|
                           (BX640452) L-lactate dehydrogenase [Bordetella bronchiseptica] [Bordetella bronchiseptica RB50]
                           387
                           77.00
                           87.33
                           4
                           1584.0
     

     






      

          
GC ORFID: 44638How Found: BLASTX

          
GC_TrimmedSeqID: 69Blast Result ID

          
Subject Sequence Name: t_PA2382Glimmer Score: 

          
Start: 1945077Stop: 1943926

          
Length: 1152


          
Start Codon: ATGTruncated Start:

          
Stop Codon: TAGTruncated Stop: 

          
Homolog: t_PA2382 translation of PA2382Homolog Bit Score 762.0

          
Other Homologs:  psyr_15may02_Scaffold3_revised_gene5120 (ORF: BLASTX 347.0), t_PA4771 (ORF: BLASTX 328.0), t_PA2382 (ORF: GLIMMER)

          
GC ORF Sequence

           
ATGAGCGTCATCACCGATATCGAAGACCTGCGCCGCCTGGCGCGCAAGCGCGTGCCGCGGATGTTCTACGAC 
TACGCCGACTCCGGTTCCTGGAGCGAAGGCACCTACCGCGCCAACCAGGACGACTTCGCCGCGATCAAGCTG 
CGCCAGCGGGTCGCGCGGAATATCGAGAACCGCTCGCTGCGCACCCGCATGCTCGGCCAGGAGATGGCCATG 
CCGGTGGCCATCGCGCCCACCGGGCTGGCCGGCATGCAGCATGCCGACGGCGAGATCCTCGCCGCCCGCGCC 
GCCGCCGAGTTCGGCGTGCGCTACACCCTGTCGACCATGAGCATCTGTTCCCTGGAGGACATCGCCACGGAA 
GTCGGCCAGCCGTTCTGGTTCCAGCTCTACGTGATGCGCGACCGCGATTTCATCGAACGCCTGATCGACCGT 
GCCAAGGCCGCCGGCTGCGACGCGCTGGTGCTGACCCTCGACCTGCAGATCATCGGCCAGCGCCACAAGGAC 
CTGAAGAACGGCCTCTCGGCGCCGCCGCGGCCGACCCTGGCCAACCTGCTGAACATCGCCACCAAGCCGCGC 
TGGGCGCTGGGCATGCTCGGCACCCGGCGTCGCGGTTTCGGCAACATAGTCGGGCACGTCAAGGGCGTCGAC 
GACATGGGCTCGCTGTCCGAGTGGACCGCCCGCCAGTTCGACCCGCGGCTGAACTGGGGCGACGTCGAATGG 
ATCAAGCGCCGCTGGGGCGGCAAGCTGGTGCTCAAGGGCATCCTCGATGCCGAGGATGCGCGGCTGGCCGCC 
GACTCCGGCGCCGATGCGCTGGTCGTCAGCAACCATGGCGGACGCCAGCTGGATGGCGCGCCCTCGACCATC 
AGCGCGCTGCCGGCGATCGTCGAGGCGGTGGGCGAGCGCATCGAGGTCTGGCTCGACAGCGGCATCCGTTCC 
GGGCAGGACGTGCTCAAGGCCATCGCCCTCGGTGCGCGCGGGACCATGATCGGCCGTCCCTATCTCTACGGG 
CTGGGCGCGCTGGGTCAGGCCGGGGTGACGCGGGCGCTGGAGATCATCGCTCGTGAGCTGGACCTGACCATG 
GCCTTCTGCGGCCATACCGACATCCGCGAGGTCGGCCGGGACATCCTGTTGCCGGGAAGCTACCCGCGATAG