NCBI Conserved Domain Search
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RPS-BLAST 2.2.9 [May-01-2004] Query= local sequence: lcl|tmpseq_0 unnamed protein product (178 letters) Database: cdd.v2.00
gnl|CDD|25595 pfam00702, Hydrolase, haloacid dehalogenase-like hydrolase. This family are structurally different from the alpha/ beta hydrolase family (pfam00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment. The rest of the fold is composed of the core alpha/beta domain gnl|CDD|10116 COG0241, HisB, Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism] gnl|CDD|10417 COG0546, Gph, Predicted phosphatases [General function prediction only] gnl|CDD|10431 COG0560, SerB, Phosphoserine phosphatase [Amino acid transport and metabolism] gnl|CDD|10517 COG0647, NagD, Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]
 Domain Relatives
    .. This CD alignment includes 3D structure. To display structure, download Cn3D!
  PSSMs producing significant alignments: Score
(bits)
E
value
 
gnl|CDD|25595 pfam00702, Hydrolase, haloacid dehalogenase-like hydrolase. Th... 49.6 2e-07
  gnl|CDD|10116 COG0241, HisB, Histidinol phosphatase and related phosphatases... 199 2e-52
  gnl|CDD|10417 COG0546, Gph, Predicted phosphatases [General function predict... 59.4 2e-10
gnl|CDD|10431 COG0560, SerB, Phosphoserine phosphatase [Amino acid transport... 36.1 0.003
  gnl|CDD|10517 COG0647, NagD, Predicted sugar phosphatases of the HAD superfa... 36.0 0.003


gnl|CDD|25595, pfam00702, Hydrolase, haloacid dehalogenase-like hydrolase. This family are structurally different from the alpha/ beta hydrolase family (pfam00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment. The rest of the fold is composed of the core alpha/beta domain.
             CD-Length = 197 residues, only  51.8% aligned
             Score = 49.6 bits (117), Expect = 2e-07
Query:  30   PIPSSIEAIARLSQAGWTVAVATNQSGIARGYYDLAVLEAMHARLRELVAEQGGEVGLIV  89
Sbjct:  96   LYPGAREALKALKERGIKLAILTNGDRA-------------NAEAVLELLGLADLFDVIV  142

Query:  90   YCPHGPDDGCDCRKPKPGMLRQIGKHYGVDLSGIWFVGDSIGDLEAARAVDCQPVLVKTG  149
Sbjct:  143  DS-----DDVGPVKPKPEIFLLALERLGVKPEEVLMVGDGVNDAPALAAAGVGVAMVNGG  197


gnl|CDD|10116, COG0241, HisB, Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]
             CD-Length = 181 residues,  94.5% aligned
             Score =  199 bits (507), Expect = 2e-52
Query:  1    MSRSLLILDRDGVINLDSDDYIKTLDEWIPIPSSIEAIARLSQAGWTVAVATNQSGIARG  60
Sbjct:  3    KDQKALFLDRDGTINIDKGDYVDSLDDFQFIPGVIPALLKLQRAGYKLVVVTNQSGIGRG  62

Query:  61   YYDLAVLEAMHARLRELVAEQGGEVGLIVYCPHGPDDGCDCRKPKPGMLRQIGKHYGVDL  120
Sbjct:  63   YFTEADFDKLHNKMLKILASQGVKIDGILYCPHHPEDNCDCRKPKPGMLLSALKEYNIDL  122

Query:  121  SGIWFVGDSIGDLEAARAVDCQPVLVKTGKGVRTLGKPLPEGTLIFDDLAAVA  173
Sbjct:  123  SRSYVVGDRLTDLQAAENAGIKGVLVLTGIGVTTDGA--GRAKWVFDSLAEFA  173


gnl|CDD|10417, COG0546, Gph, Predicted phosphatases [General function prediction only]
             CD-Length = 220 residues, only  64.1% aligned
             Score = 59.4 bits (143), Expect = 2e-10
Query:  19   DDYIKTLDEWIPIPSSIEAIARLSQAGWTVAVATNQSGIARGYYDLAVLEAMHARLRELV  78
Sbjct:  79   LTAYAELLESRLFPGVKELLAALKSAGYKLGIVTNKP---------------ERELDILL  123

Query:  79   AEQG-GEVGLIVYCPHGPDDGCDCRKPKPGMLRQIGKHYGVDLSGIWFVGDSIGDLEAAR  137
Sbjct:  124  KALGLADYFDVIVG----GDDVPPPKPDPEPLLLLLEKLGLDPEEALMVGDSLNDILAAK  179

Query:  138  AVDCQPVLVKTGKGVRTLGKPLPEGTLIFDDLAAVASALLQ  178
Sbjct:  180  AAGVPAVGVTWGYNSREELAQA-GADVVIDSLAELLALLAE  219


gnl|CDD|10431, COG0560, SerB, Phosphoserine phosphatase [Amino acid transport and metabolism]
             CD-Length = 212 residues, only  63.7% aligned
             Score = 36.1 bits (83), Expect = 0.003
Query:  15   NLDSDDYIKTLDEWIPI-PSSIEAIARLSQAGWTVAVAT-NQSGIARGYYDLAVLEAMHA  72
Sbjct:  62   GLPVEVLEEVREEFLRLTPGAEELVAALKAAGAKVVIISGGFTFLVEPIAER--LGIDYV  119

Query:  73   RLRELVAEQGGEVGLIVYCPHGPDDGCDCRKPKPGMLRQIGKHYGVDLSGIWFVGDSIGD  132
Sbjct:  120  VANELEIDDGKLTGRVVGPI------CD-GEGKAKALRELAAELGIPLEETVAYGDSAND  172

Query:  133  LEAARAVDCQPVLVKTGKGVRTLGK  157
Sbjct:  173  LPMLEAAG-LPIAVNPKPKLRALAD  196


gnl|CDD|10517, COG0647, NagD, Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]
             CD-Length = 269 residues, only  28.3% aligned
             Score = 36.0 bits (83), Expect = 0.003
Query:  103  KPKPGMLRQIGKHYGVDLSGIWFVGDSI-GDLEAARAVDCQPVLVKTGK-GVRTLGKPLP  160
Sbjct:  190  KPSPAIYEAALEKLGLDRSEVLMVGDRLDTDILGAKAAGLDTLLVLTGVSSAEDLDRAEV  249

Query:  161  EGTLIFDDLAAVASAL  176
Sbjct:  250  KPTYVVDSLAELITAL  265

Citing CD-Search: Marchler-Bauer A, Anderson JB, DeWeese-Scott C, Fedorova ND, Geer LY, He S, Hurwitz DI, Jackson JD, Jacobs AR, Lanczycki CJ, Liebert CA, Liu C, Madej T, Marchler GH, Mazumder R, Nikolskaya AN, Panchenko AR, Rao BS, Shoemaker BA, Simonyan V, Song JS, Thiessen PA, Vasudevan S, Wang Y, Yamashita RA, Yin JJ, and Bryant SH (2003), "CDD: a curated Entrez database of conserved domain alignments", Nucleic Acids Res. 31:383-387.