RPS-BLAST 2.2.9 [May-01-2004]
Query= local sequence: lcl|tmpseq_0 unnamed protein product
         (806 letters)

Database: cdd.v2.00

	PSSMs producing significant alignments:		Score (bits)	E value
	gnl|CDD|17769	cd00075, HATPase_c, Histidine kinase-like ATPases; This family...	62.3	2e-10
	gnl|CDD|24279	smart00433, TOP2c, TopoisomeraseII; Eukaryotic DNA topoisomera...	678	0.0
	gnl|CDD|24279	smart00433, TOP2c, TopoisomeraseII; Eukaryotic DNA topoisomera...	114	5e-26
	gnl|CDD|25316	smart00387, HATPase_c, Histidine kinase-like ATPases; Histidin...	68.4	3e-12
	gnl|CDD|25440	pfam00204, DNA_gyraseB, DNA gyrase B. This family represents t...	197	4e-51
	gnl|CDD|25662	pfam00986, DNA_gyraseB_C, DNA gyrase B subunit, carboxyl termi...	121	2e-28
	gnl|CDD|25917	pfam02518, HATPase_c, Histidine kinase-, DNA gyrase B-, and HS...	68.9	2e-12
	gnl|CDD|8119	pfam01751, Toprim, Toprim domain. This is a conserved region f...	38.0	0.005
	gnl|CDD|10062	COG0187, GyrB, Type IIA topoisomerase (DNA gyrase/topo II, top...	900	0.0
	gnl|CDD|10062	COG0187, GyrB, Type IIA topoisomerase (DNA gyrase/topo II, top...	135	2e-32
	gnl|CDD|10197	COG0323, MutL, DNA mismatch repair enzyme (predicted ATPase) [...	37.6	0.005

gnl|CDD|17769, cd00075, HATPase_c, Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins

             CD-Length = 103 residues,  85.4% aligned
             Score = 62.3 bits (151), Expect = 2e-10

Query:  38   LHHMVFEVVDNSIDEALAGYCSEISITIHTDE---SITVRDNGRGIPVDIHKEEGVSAAE  94
Sbjct:  1    LQQVLLNLLSNAIKHTPEG-GGRITISVERDGDHLEIRVEDNGPGIPEEDLE--------  51

Query:  95   VIMTVLHAGGKFDDNTYKVSGGLHGVGVSVVNALSHELRLTIR  137
Sbjct:  52   ------RIFERFSDGSRSRKGGGTGLGLSIVKKLVELHGGRIE  88

---

             CD-Length = 594 residues,  87.7% aligned
             Score =  678 bits (1751), Expect = 0.0

Query:  37   GLHHMVFEVVDNSIDEALAGYCSEISITIHTDESITVRDNGRGIPVDIHKEEGVSAAEVI  96
Sbjct:  1    GLHHLVDEIVDNAADEALAGYMDTIKVTIDKDNSISVEDNGRGIPVEIHPKEKKYAPEVI  60

Query:  97   MTVLHAGGKFDDNTYKVSGGLHGVGVSVVNALSHELRLTIRRHNKVWEQVYH-HGVPQFP  155
Sbjct:  61   FTVLHAGGKFDDDEYKVSGGLHGVGASVVNALSTEFEVEVARDGKEYKQSFSNNGKPLSE  120

Query:  156  LREVGETDGSGTEVHFKPSPETFSNI-HFSWDILAKRIRELSFLNSGVGILLRDERTGKE  214
Sbjct:  121  PKIIGDTKKDGTKVTFKPDLEIFGMTTDDDFELLKRRLRELAFLNKGVKITLNDERSDEE  180

Query:  215  ELFKYEGGLKAFVEYLNTNKTAVNEVFHFNVQREEDGVGVEVALQWNDSFNENLLCFTNN  274
Sbjct:  181  VTFLFEGGIKDYVELLNKNKELLSPEPTYIEG-EKDNIRVEVAFQYTDGYSENIVSFVNN  239

Query:  275  IPQRDGGTHLAGFRSALTRNLNNYIEAEGLAKKFKIATTGDDAREGLTAIISVKVPDPKF  334
Sbjct:  240  IATTEGGTHENGFKDALTRVINEYAKKKKKLKEKNI--KGEDVREGLTAFISVKIPEPQF  297

Query:  335  SSQTKDKLVSSEVKTAVEQEMGKYFADFLLENPNEAKAVVGKMIDAARAREAARKAREMT  394
Sbjct:  298  EGQTKEKLGTSEVRFGVEKIVSECLLSFLEENPVLASKIVEKVLLAAKARAAAKKARELT  357

Query:  395  RRKGALDIAGLPGKLADCQEKDPALSELYIVEGDSAGGSAKQGRNRRTQAILPLKGKILN  454
Sbjct:  358  RKKSKLSSISLPGKLADASSAGPKKCELFLVEGDSAGGSAKSGRDRDFQAILPLRGKLLN  417

Query:  455  VEKARFDKMLSSQEVGTLITALGCGIGREEYNIDKLRYHNIIIMTDADVDGSHIRTLLLT  514
Sbjct:  418  VEKASLDKILKNEEIQALITALGLGIG-KDFDIEKLRYGKIIIMTDADVDGSHIKGLLLT  476

Query:  515  FFFRQMPELIERGYIYIAQPPLYKVKRGKQEQYIKDDQAMEEYMTQ  560
Sbjct:  477  FFYRYMPPLIEAGFVYIAIPPLYKVTKGKKKYVYSFYS-LDEYEKW  521

             CD-Length = 594 residues, only  15.7% aligned
             Score =  114 bits (286), Expect = 5e-26

Query:  709  VQKGERKRPISAF--KDGLDWLMAEGTKRH-SIQRYKGLGEMNPEQLWETTMDPNVRRML  765
Sbjct:  501  VTKGKKKYVYSFYSLDEYEKWLETKGNKKKYEIQRYKGLGEMNADQLWETTMDPERRTLL  560

Query:  766  KVTIEDAIAADQIFNTLMGDAVEPRRDFIESNA  798
Sbjct:  561  FVTLDDADEADLIFSALMGDKVEPRKEWIEENA  593

gnl|CDD|25316, smart00387, HATPase_c, Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.

             CD-Length = 112 residues,  85.7% aligned
             Score = 68.4 bits (167), Expect = 3e-12

Query:  34   DGTGLHHMVFEVVDNSIDEALAGYCSEISITIHTDE---SITVRDNGRGIPVDIHKEEGV  90
Sbjct:  2    DPDRLRQVLSNLLDNAIKYTPEG--GRITVTLEREGDHVEITVEDNGPGIP---------  50

Query:  91   SAAEVIMTVLHAGGKFDDNTYKVSGGLHGVGVSVVNALSHELRLTIRRHNK  141
Sbjct:  51   --PEDLEKIFEPFFRTDKRSRKIGG--TGLGLSIVKKLVELHGGEISVESE  97

---

gnl|CDD|25440, pfam00204, DNA_gyraseB, DNA gyrase B. This family represents the second domain of DNA gyrase B which has a ribosomal S5 domain 2-like fold. This family is structurally related to PF01119.

             CD-Length = 170 residues, 100.0% aligned
             Score =  197 bits (503), Expect = 4e-51

Query:  222  GLKAFVEYLNTNKTAV-NEVFHFNVQREEDGVGVEVALQW-NDSFNENLLCFTNNIPQRD  279
Sbjct:  1    GIKLYVKYLNESKEPIHPEPIVYEG---ENGIRVEVALQWSNDGYFEQILSFNNNIPTTE  57

Query:  280  GGTHLAGFRSALTRNLNNYIEAEGLAKKFKIATTGDDAREGLTAIISVKVPDPKFSSQTK  339
Sbjct:  58   GGTHVNGFKDALTRALNEYAKKKNKLKK-KDKLTGEDVREGLTAVISVKIPNPQFEGQTK  116

Query:  340  DKLVSSEVKTAVEQEMGKYFADFLLENPNEAKAVVGKMIDAARAREAARKAREM  393
Sbjct:  117  EKLGSSEVRFGVECIVSEKLLFFLEENPVDAKAIIEKAADAAKAREAAKKAREL  170

---

             CD-Length = 67 residues,  97.0% aligned
             Score =  121 bits (306), Expect = 2e-28

Query:  731  EGTKRHSIQRYKGLGEMNPEQLWETTMDPNVRRMLKVTIEDAIAADQIFNTLMGDAVEPR  790
Sbjct:  3    NKKGKYEIQRYKGLGEMNPEQLWETTMDPETRTLLQVTIEDAAEADELFSILMGDKVEPR  62

Query:  791  RDFIE  795
Sbjct:  63   REFIE  67

gnl|CDD|25917, pfam02518, HATPase_c, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.

             CD-Length = 111 residues,  87.4% aligned
             Score = 68.9 bits (168), Expect = 2e-12

Query:  34   DGTGLHHMVFEVVDNSIDEALAGYCSEISITIHTDE---SITVRDNGRGIPVDIHKEEGV  90
Sbjct:  2    DEDRLRQVLSNLLDNAIKHAPAG--GEITVRLEREGGDVRITVEDNGIGIP---------  50

Query:  91   SAAEVIMTVLHAGGKFDDNTYKVSGGLHGVGVSVVNALSHELRLTIRRHNKV  142
Sbjct:  51   --PEDLERIFEPFFTTDGDSRKIGG--TGLGLSIVKELVELHGGTITVESEP  98

---

gnl|CDD|8119, pfam01751, Toprim, Toprim domain. This is a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins. Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely abolish DnaG type primase activity. DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesises the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division. This family also includes the atypical archaeal A subunit from type II DNA topoisomerases. Type II DNA topoisomerases catalyse the relaxation of DNA supercoiling by causing transient double strand breaks.

             CD-Length = 84 residues,  91.7% aligned
             Score = 38.0 bits (88), Expect = 0.005

Query:  450  GKILNVEKARFDKMLSS--QEVGTLITALGCGIGREEYNIDKLRYHN--IIIMTDADVDG  505
Sbjct:  1    KVLIIVEGPSDAIALEKAGGYRGNVVALLGHLLTKEQLKLLKKLAKKDEVILATDPDREG  60

Query:  506  SHIRTLLLTFFFRQMPE  522
Sbjct:  61   EAIAWKLLELLKPYGKK  77

---

             CD-Length = 635 residues,  87.9% aligned
             Score =  900 bits (2328), Expect = 0.0

Query:  2    SENNTYDSSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNSIDEALAGYCSEI  61
Sbjct:  1    SKTNNYDASSIQVLEGLEAVRKRPGMYIGSTGDGRGLHHLVWEVVDNSIDEALAGYADRI  60

Query:  62   SITIHTDESITVRDNGRGIPVDIHKEEGVSAAEVIMTVLHAGGKFDDNTYKVSGGLHGVG  121
Sbjct:  61   DVTLHEDGSISVEDNGRGIPVDIHPKEKVSAVEVIFTVLHAGGKFDNDSYKVSGGLHGVG  120

Query:  122  VSVVNALSHELRLTIRRHNKVWEQVYHHGVPQFPLREVGETD--GSGTEVHFKPSPETFS  179
Sbjct:  121  VSVVNALSTWLEVEVKRDGKIYRQRFERGVPVTPLEVIGSTDTKKTGTKVRFKPDPEIFG  180

Query:  180  NIHFSWDILAKRIRELSFLNSGVGILLRDERTGKEEL-FKYEGGLKAFVEYLNTNKTAVN  238
Sbjct:  181  ETEFDYEILKRRLRELAFLNKGVKITLTDERTGEEKKEFHYEGGLKDYVEYLNKGKTPLH  240

Query:  239  EVFHFNVQREEDGVGVEVALQWNDSFNENLLCFTNNIPQRDGGTHLAGFRSALTRNLNNY  298
Sbjct:  241  EE-IFYFNGEKDGIAVEVALQWNDGYSENILSFVNNIPTREGGTHEAGFRSALTRAINEY  299

Query:  299  IEAEGLAKKFKIATTGDDAREGLTAIISVKVPDPKFSSQTKDKLVSSEVKTAVEQEMGKY  358
Sbjct:  300  AKKKNLLKEGDL--TGDDIREGLTAVISVKIPDPQFEGQTKEKLGNSEVRSIVEKLVSEA  357

Query:  359  FADFLLENPNEAKAVVGKMIDAARAREAARKAREMTRRKGALDIAGLPGKLADCQEKDPA  418
Sbjct:  358  FSLFLEENPQEAKKIVEKAIAAAKAREAARKARELTRRKSALDIPGLPGKLADCTSKDPE  417

Query:  419  LSELYIVEGDSAGGSAKQGRNRRTQAILPLKGKILNVEKARFDKMLSSQEVGTLITALGC  478
Sbjct:  418  KSELFLVEGDSAGGSAKQGRDREFQAILPLRGKILNVEKARLDKILKNEEIQTIITALGT  477

Query:  479  GIGREEYNIDKLRYHNIIIMTDADVDGSHIRTLLLTFFFRQMPELIERGYIYIAQPPLYK  538
Sbjct:  478  GIG-KDFDLEKLRYHKIIIMTDADVDGAHIRTLLLTFFYRYMPPLIENGHVYIAQPPLYK  536

Query:  539  VKRGKQEQYIKDDQAMEEYMTQ  560
Sbjct:  537  VKKGKKTFYAYDDEELEKLLER  558

             CD-Length = 635 residues, only  11.5% aligned
             Score =  135 bits (341), Expect = 2e-32

Query:  734  KRHSIQRYKGLGEMNPEQLWETTMDPNVRRMLKVTIEDAIAADQIFNTLMGDAVEPRRDF  793
Sbjct:  563  KGYEIQRYKGLGEMNPDQLWETTMDPETRRLLQVTIEDADEADEIFSTLMGDKVEPRRNF  622

Query:  794  IESNALAVSNLDV  806
Sbjct:  623  IEENALFVENLDI  635

             CD-Length = 638 residues, only   6.4% aligned
             Score = 37.6 bits (87), Expect = 0.005

Query:  41   MVFEVVDNSIDEALAGYCSEISITIHTD--ESITVRDNGRGIPVD  83
Sbjct:  27   VVKELVENSLD---AG-ATRIDIEVEGGGLKLIRVRDNGSGIDKE  67