Score E
Sequences producing significant alignments: (bits) Value
gnl|CDD|10079 COG0204, PlsC, 1-acyl-sn-glycerol-3-phosphate... 133 6e-32
gnl|CDD|20634 KOG2848, KOG2848, 1-acyl-sn-glycerol-3-phosph... 132 8e-32
gnl|CDD|24304 smart00563, PlsC, Phosphate acyltransferases;... 91 2e-19
gnl|CDD|25778 pfam01553, Acyltransferase, Acyltransferase. ... 83 4e-17
gnl|CDD|19293 KOG1505, KOG1505, Lysophosphatidic acid acylt... 53 6e-08
gnl|CDD|20633 KOG2847, KOG2847, Phosphate acyltransferase [... 39 0.001
gnl|CDD|11829 COG2121, COG2121, Uncharacterized protein con... 38 0.003
gnl|CDD|18557 KOG0763, KOG0763, Mitochondrial ornithine tra... 33 0.052
gnl|CDD|7890 pfam01063, Aminotran_4, Aminotransferase class... 31 0.34
gnl|CDD|16567 cd00449, PLPDE_IV, PyridoxaL 5'-Phosphate Dep... 31 0.43
gnl|CDD|21674 KOG3896, KOG3896, Dynactin, subunit p62 [Cell... 30 0.65
gnl|CDD|9990 COG0115, IlvE, Branched-chain amino acid amino... 27 6.5
>gnl|CDD|10079 COG0204, PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid
metabolism]
Length = 255
Score = 133 bits (334), Expect = 6e-32
Identities = 70/240 (29%), Positives = 109/240 (45%), Gaps = 10/240 (4%)
Query: 12 FYLLLSASAFVWGTLSFFIAPILPFRARYRFVVQNWCRFAIWLTRVVAGIRYEVRGLENI 71
Sbjct: 1 LRLALLLILVILFLLLPLPLALIALFRLRRPVLRRWLRFLVLLLLLLFGLRVEVEGLENL 60
Query: 72 PE-KPCVILSKHQSTWETFFLSGFF---EPLSQVLKRELLYVPFFGWALALLKPIAIDRS 127
Sbjct: 61 PKGGPALVVANHQSFLDPLLLSLALPRRGPVRFVAKKELFKVPLLGWLLRLLGAIPVDRE 120
Query: 128 QPKLALKQLAKQGDECLKKGAWVLIFPEGTRIPVGQ-MGKFSRGGTALAVNAGLPVLPIA 186
Sbjct: 121 NPDDETLRAAVA--RLKAGGRSLVIFPEGTRSRGGEELLPFKRGAARLALEAGVPIVPVA 178
Query: 187 HNAGQYWPKAGWAKYPGTIQVVIGPAMHAEGEGPRAIAELNQRAEAWVSETMAEISPIQQ 246
Sbjct: 179 IVGAE---ELFPSLKKGKVKVRIGPPIDISALPEPLLPELAEAVEQLARPILLELLPRYA 235
>gnl|CDD|20634 KOG2848, KOG2848, 1-acyl-sn-glycerol-3-phosphate acyltransferase
[Lipid transport and metabolism]
Length = 276
Score = 132 bits (334), Expect = 8e-32
Identities = 69/239 (28%), Positives = 109/239 (45%), Gaps = 10/239 (4%)
Query: 7 IRTVLFYLLLSASAFVWGTLSFFIAPILPFRARYRFVVQNWCRFAIWLTRVVAGIRYEVR 66
Sbjct: 28 FRCAFYGAICSFYGVI---ASPVCLLRGGRSVENHFIAKLWFHSMKYLL----GLRFEVR 80
Query: 67 GLENIP-EKPCVILSKHQSTWETFFLSGFFEP-LSQVLKRELLYVPFFGWALALLKPIAI 124
Sbjct: 81 GEENLPKSKPAVIVSNHQSSLDILGMGSIWPKNCVVIAKRSLFYVPIFGLAMYLSGVVFI 140
Query: 125 DRSQPKLALKQLAKQGDECLKKGAWVLIFPEGTRIPVGQMGKFSRGGTALAVNAGLPVLP 184
Sbjct: 141 DRSRREKAIDTLDKCAERMKKENRKVWVFPEGTRNKEGRLLPFKKGAFHLAVQAQVPIVP 200
Query: 185 IA-HNAGQYWPKAGWAKYPGTIQVVIGPAMHAEGEGPRAIAELNQRAEAWVSETMAEIS 242
Sbjct: 201 VVFSSYGDFYSTKEKVFNSGNVIVRVLPPIPTEGLTKDDVDVLSDECRSAMLETFKEIS 259
>gnl|CDD|24304 smart00563, PlsC, Phosphate acyltransferases; Function in
phospholipid biosynthesis and have either
glycerolphosphate, 1-acylglycerolphosphate, or
2-acylglycerolphosphoethanolamine acyltransferase
activities. Tafazzin, the product of the gene mutated in
patients with Barth syndrome, is a member of this family
Length = 118
Score = 91.2 bits (226), Expect = 2e-19
Identities = 43/117 (36%), Positives = 64/117 (54%), Gaps = 5/117 (4%)
Query: 76 CVILSKHQSTWETFFLSGFFEPLSQ----VLKRELLYVPFFGWALALLKPIAIDRSQPKL 131
Sbjct: 1 ALVVANHQSFLDPLVLSALLPRKLRRVRFVAKKELFYVPLLGWLLRLAGAIFIDRSRGRK 60
Query: 132 ALKQLAKQGDECLKKGAWVLIFPEGTRIPVGQMGKFSRGGTALAVNAGLPVLPIAHN 188
Sbjct: 61 DRAALREAV-RLLREGEWLLIFPEGTRSRPGKLLPFKKGAARLALEAGVPIVPVAIR 116
>gnl|CDD|25778 pfam01553, Acyltransferase, Acyltransferase. This family contains
acyltransferases involved in phospholipid biosynthesis
and other proteins of unknown function. This family also
includes tafazzin, the Barth syndrome gene
Length = 132
Score = 83.5 bits (206), Expect = 4e-17
Identities = 50/130 (38%), Positives = 70/130 (53%), Gaps = 5/130 (3%)
Query: 62 RYEVRGLENIPEK-PCVILSKHQSTWETFFLSGFF----EPLSQVLKRELLYVPFFGWAL 116
Sbjct: 1 RIRVHGLENLPEAGPAIVVANHQSWLDPLVLSLLLYKRPDRPVFIAKKILLTDPLLGPLM 60
Query: 117 ALLKPIAIDRSQPKLALKQLAKQGDECLKKGAWVLIFPEGTRIPVGQMGKFSRGGTALAV 176
Sbjct: 61 RLLGLIFIDRENKKRALEALREAVELLRKGELPVLIFPEGTRSRNGRLLPFKKGAFHLAV 120
Query: 177 NAGLPVLPIA 186
Sbjct: 121 QAGVPIVPVA 130
>gnl|CDD|19293 KOG1505, KOG1505, Lysophosphatidic acid acyltransferase LPAAT and
related acyltransferases [Lipid transport and metabolism]
Length = 346
Score = 53.4 bits (128), Expect = 6e-08
Identities = 41/160 (25%), Positives = 64/160 (40%), Gaps = 13/160 (8%)
Query: 9 TVLFYLLLSASAFVWGTLSFFIAPILPFRARYRFVVQNWCRFAIWLTR-VVAGIRYEVRG 67
Sbjct: 8 VIAFIQLVVFVLVSAIVLQLF--SKLLWRLLYKLYSGLLLFLASWYAGSEVNGYGDDVTG 65
Query: 68 LENIPEKPCVILSKHQSTWETFFL------SGFFEPLSQVLKRELLYVPFFGWALALLKP 121
Sbjct: 66 DKYGKE-RALLIANHQSEVDWLYLWTYAQRKGVLGNVKIVLKKSLKYLPIFGWGMWFHGF 124
Query: 122 IAIDR--SQPKLALKQLAKQGDECLKKGAWVLIFPEGTRI 159
Sbjct: 125 IFLERNWEKDEKTLISLLKHLKDSPDPY-WLLLFPEGTRF 163
>gnl|CDD|20633 KOG2847, KOG2847, Phosphate acyltransferase [Lipid transport and
metabolism]
Length = 286
Score = 39.2 bits (91), Expect = 0.001
Identities = 49/205 (23%), Positives = 79/205 (38%), Gaps = 42/205 (20%)
Query: 72 PEKPCVILSKHQSTWETFFLSGFFEPLSQVLKRELLYV----------PFFGWALALLKP 121
Sbjct: 67 PNRPLITVSNHMSCVDDPLVWGILKLRLFLNLKNIRWTLAAHDICFTNPFHSNFFSLGKC 126
Query: 122 IAIDRSQPKLALKQLAKQGDECLKK---GAWVLIFPEGTRIPVG-QMGKFSRGGTALAVN 177
Sbjct: 127 LPIVRGE---GVYQ--KGMDFAIEKLNDGSWVHIFPEGKVNQMEKEMLRFKWGIGRLILE 181
Query: 178 AGLP--VLPIAH--------NAGQYWPKAGWAKYPGTIQVVIGPAMHAEGEGPRAIAELN 227
Sbjct: 182 APKPPIVLPIWHTGMEDIMPEAPPYVPRFG-----KTVTVTIGDPINFD------DVEWT 230
Query: 228 QRAEAWVSETMAEI--SPIQQRVSH 250
Sbjct: 231 VLAEKVSTPKLRKALTDEIQERFQD 255
>gnl|CDD|11829 COG2121, COG2121, Uncharacterized protein conserved in bacteria
[Function unknown]
Length = 214
Score = 38.0 bits (88), Expect = 0.003
Identities = 48/225 (21%), Positives = 84/225 (37%), Gaps = 35/225 (15%)
Query: 33 ILPFRARYRFVVQNWCRFAIWLTRVV-AGIRYEVRGLENIP---EKPCVILSKHQSTWET 88
Sbjct: 1 LKKFLKNSKFVISILTSLLYGYLRLVYLTSRWKAGGADNNALANEKPGIVAFWHGQ---- 56
Query: 89 FFLSGFFEP--------LSQVLKRELLYVPFFGWALALLKPIAIDRSQPKLALKQLAKQG 140
Sbjct: 57 LALGPFAFPKGKKIYAMVSPSRDGELIARL-----LEKFGLRVIRGSSNKGGISAL-RAL 110
Query: 141 DECLKKGAWVLIFPEGTRIPVGQMGKFSRGGTALAVNAGLPVLPIAHNAGQYWPKAGWAK 200
Sbjct: 111 LKALKQGKSIAITPDGPKGPVHKIGD---GIIALAQKSGVPIIPVGVATSRCWRLKTWDK 167
Query: 201 YP-----GTIQVVIGPAMHAEGEGPRAIAELNQRAEAWVSETMAE 240
Sbjct: 168 TIIPLPFGKIKIVLGEPIEVDAD-----KDKEELEEKRQEVSLAL 207
>gnl|CDD|18557 KOG0763, KOG0763, Mitochondrial ornithine transporter [Energy
production and conversion]
Length = 301
Score = 33.4 bits (76), Expect = 0.052
Identities = 31/129 (24%), Positives = 50/129 (38%), Gaps = 12/129 (9%)
Query: 63 YEVRGLENIPEKPCVILSKHQSTWETFFLSGFFEPLSQVLKRELL-YVPFFG-WALALLK 120
Sbjct: 144 REMKNSGKIAKSINTPWSVTRYILKKDGPRGFYHGLSSTLLREVPGYFFFFGGYELSRSL 203
Query: 121 PIAIDRSQPKLALKQLAKQGD---ECLKKGAWVLIFPEG---TRIPVGQMGKFSRGGTAL 174
Sbjct: 204 LASDGQSKDEIGPVRTMLAGGVGGICL----WTSVFPADVIKSRIQVLSMNGFMFTLGAV 259
Query: 175 AVNAGLPVL 183
Sbjct: 260 VRNEGILAL 268
>gnl|CDD|7890 pfam01063, Aminotran_4, Aminotransferase class IV. The D-amino acid
transferases (D-AAT) are required by bacteria to catalyse
the synthesis of D-glutamic acid and D-alanine, which are
essential constituents of bacterial cell wall and are the
building block for other D-amino acids. Despite the
difference in the structure of the substrates, D-AATs and
L-ATTs have strong similarity
Length = 276
Score = 31.0 bits (70), Expect = 0.34
Identities = 11/27 (40%), Positives = 16/27 (59%)
Query: 218 EGPRAIAELNQRAEAWVSETMAEISPI 244
Sbjct: 225 ERPITLEELLTADEAFGSGTAAEVTPV 251
>gnl|CDD|16567 cd00449, PLPDE_IV, PyridoxaL 5'-Phosphate Dependent Enzymes class IV
(PLPDE_IV). This D-amino acid superfamily, one of five
classes of PLPDE, consists of branched-chain amino acid
aminotransferases (BCAT), D-amino acid transferases
(DAAT), and 4-amino-4-deoxychorismate lyases (ADCL). BCAT
catalyzes the reversible transamination reaction between
the L-branched-chain amino and alpha-keto acids. DAAT
catalyzes the synthesis of D-glutamic acid and D-alanine,
and ADCL converts 4-amino-4-deoxychorismate to
p-aminobenzoate and pyruvate. Except for a few enzymes,
i. e., Escherichia coli and Salmonella BCATs, which are
homohexamers arranged as a double trimer, the class IV
PLPDEs are homodimers. Homodimer formation is required
for catalytic activity
Length = 279
Score = 30.6 bits (69), Expect = 0.43
Identities = 11/27 (40%), Positives = 15/27 (55%)
Query: 218 EGPRAIAELNQRAEAWVSETMAEISPI 244
Sbjct: 229 ERPITLEELLTADEVFGSGTAAEITPV 255
>gnl|CDD|21674 KOG3896, KOG3896, Dynactin, subunit p62 [Cell motility]
Length = 449
Score = 29.7 bits (66), Expect = 0.65
Identities = 19/66 (28%), Positives = 29/66 (43%), Gaps = 8/66 (12%)
Query: 194 PKAGWAKYPGTIQVVIGPAMHAEGEGPRAIAELNQRAEAWVSETMAEISPIQQRVSHP-- 251
Sbjct: 189 RKKGLAKEPEMNKVDIAPA-HAPTEVETLPEEIKTR-----PDNLREVTTLDQRIMQPLI 242
Query: 252 EPSVVS 257
Sbjct: 243 QPVISE 248
>gnl|CDD|9990 COG0115, IlvE, Branched-chain amino acid
aminotransferase/4-amino-4-deoxychorismate lyase [Amino
acid transport and metabolism / Coenzyme metabolism]
Length = 284
Score = 26.6 bits (58), Expect = 6.5
Identities = 13/39 (33%), Positives = 20/39 (51%), Gaps = 3/39 (7%)
Query: 218 EGPRAIAELNQRAEAWVSETMAEISP---IQQRVSHPEP 253
Sbjct: 229 ERPITLEDLKQADEVFLTNTAAGVTPVGLIDGRVGQPGP 267
Lambda K H
0.324 0.139 0.440
Gapped
Lambda K H
0.267 0.0435 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 1100, Extension: 100
Number of Hits to DB: 4,521,117
Number of Sequences: 0
Number of extensions: 450567
Number of successful extensions: 256
Number of sequences better than 10.0: 1
Number of HSP's better than 10.0 without gapping: 1
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 245
length of query: 0
length of database: 5,506,404
effective HSP length: 92
effective length of query: -92
effective length of database: 3,846,816
effective search space: -353907072
effective search space used: 634724640
T: 11
A: 40
X1: 1500 (700.9 bits)
X2: 3800 (1463.8 bits)
X3: 6400 (2465.3 bits)
S1: 4000 (1872.0 bits)
S2: 60 (27.6 bits)